Results 31 to 40 of about 148,120 (266)

Collagen‐Based Gut‐on‐Chip for In Vitro Modeling of Intestinal Barrier Function and Host‐Pathogen Interactions

Advanced Materials Technologies, EarlyView.
A collagen‐based gut‐on‐chip model replicates the intestinal extracellular matrix, supporting villi‐like structures, tight junctions, and mucin production. This biomimetic platform enables rapid epithelial differentiation and functional barrier formation.
Fernanda López García, Jacques Leng, Hugo de Oliveira, Pierre Nassoy, Karine Dementhon   +4 more
wiley   +1 more source

Hemozoin induces neuronal injury primarily characterized by axon rupture and mitochondrial damage in experimental cerebral malaria

Parasites & Vectors
Background Cerebral malaria (CM) is the most serious and fatal neurological complication of Plasmodium falciparum infection, which can cause death or long-term neurological sequelae.
Tong Li, Dongmei Dang, Yan Shen, Jun Wang, Yuxiao Huang, Qinghao Zhu, Yi Wang, Chao Yang, Ganze Li, Jiayi Sun, Aining Zhang, Pengtao Li, Jiao Liang, Ya Zhao   +13 more
doaj   +1 more source

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

Advanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He, Jiapeng Bao, Shukang Deng, Weijie Zang, Haoming Yan, Zihao Zhao, Guangze Zhang, Ruiqing Liu, Junjie Chen, Yilin Hu, Wanjiang Xue   +10 more
wiley   +1 more source

Neurons upregulate PD-L1 via IFN/STAT1/IRF1 to alleviate damage by CD8+ T cells in cerebral malaria

Journal of Neuroinflammation
Background Cerebral malaria (CM) is the most lethal complication of malaria, and survivors usually endure neurological sequelae. Notably, the cytotoxic effect of infiltrating Plasmodium-activated CD8+ T cells on cerebral microvasculature endothelial ...
Yi Wang, Yan Shen, Jiao Liang, Shubiao Wang, Yuxiao Huang, Qinghao Zhu, Xizhi Zhang, Kangjie Yu, Guodong Tong, Chao Yang, Yinghui Li, Jun Wang, Ya Zhao   +12 more
doaj   +1 more source

Indoor Microbiological air Pollution in the Hospital

Quality of Life (Banja Luka) - APEIRON, 2020
Microorganisms in the air of occupational indoor environments are associated with a wide range of adverse health effects with major public health impact. The aim of this study was testing the presence of microbiological parameters (bacteria and fungi) and microclimatic parameters (temperature and relative humidity) in the clinical hospital “St.
Ljiljana Stojanović Bjelić, Predrag Ilić, Zia Ur Rahman Farooqi   +2 more
openaire   +2 more sources

Polychip‐A High‐Throughput Droplet Microfluidics Platform for Interrogating Microbial Interactions

Advanced Science, EarlyView.
Polychip, a fully integrated droplet microfluidics platform, enables high‐throughput, single‐cell resolution screening of polymicrobial interactions. By seamlessly combining six automated microfluidics operations on a single chip, the system accelerates antimicrobial discovery by 11 to 14 times compared to traditional robotic methods.
Jeong Jae Han, Adrian Ryan Guzman, Aifen Zhou, Han Zhang, Rohit Gupte, Haemin Jung, Kaylee Delgado, Sini Skariah, Ali Sultan, Arul Jayaraman, Paul de Figueiredo, Arum Han   +11 more
wiley   +1 more source

Assessing the generation and dispersal of respiratory particles using upper respiratory commensal bacteria as index organisms for respiratory pathogens

Scientific Reports
There is a need to better understand the dispersal and spread of respiratory pathogens. However, carrying out controlled microbiology-based simulation studies is difficult, particularly if the target organism is highly pathogenic or is currently unknown.
Patricia Barkoci, Wilhemina D’Costa, Neville Q. Verlander, Nicola Yaxley, Ginny Moore   +4 more
doaj   +1 more source

Seasonal microbiological quality of air in veterinary practices in Poland

Annals of Agricultural and Environmental Medicine, 2015
Numerous studies focused on the bioaerosols in the areas of industry, agriculture and animal husbandry, concerning both residential and public buildings, have been conducted continuously for many years. The aim of the present work was to determine the concentration and composition of mesophilic bacterial flora in the air of selected medical and ...
Jolanta Sitkowska, Wiesław Sitkowski, Łukasz Sitkowski, Krzysztof Lutnicki, Łukasz Adamek, Piotr Wilkołek   +5 more
openaire   +3 more sources

SERS Facemask for Rapid and Portable Sensing Mycobacterium Tuberculosis Antigens for TB Screening

Advanced Science, EarlyView.
Our study introduced an Au─Ag embedded covalent organic framework (U@COF) ‐mediated facemask for sensing TB antigen ESAT‐6/CFP‐10 complex in clinical droplet samples toward TB screening. Practical analysis of clinical samples demonstrated the availability of our facemask, which is capable of identifying the TB subjects (N = 17) from healthy candidates (
Lingzhi Chen, Jiaqi Yu, Jing Xu, Lingqi Chen, Ninghao Zhang, Wenrui Li, Runmin Zeng, Xiaomin Luo, Yiqun Chang, Jiayin Lai, Wenshi Huang, Xiaochen Liang, Ting Zhao, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Xueqin Huang, Haibo Zhou, Junxia Zheng   +20 more
wiley   +1 more source

Standardization, validation, and comparative evaluation of a convenient surrogate recombinant vesicular stomatitis virus plaque reduction test for quantification of Hantaan orthohantavirus (HTNV) neutralizing antibodies

Virology Journal
Hantaan orthohantavirus (HTNV) is responsible for severe hemorrhagic fever with renal syndrome (HFRS), which has a case fatality rate of 1% to 10%. Currently, the inactive vaccine licensed in endemic areas elicit low levels of neutralizing antibodies ...
Jing Wei, Hui Zhang, Jiawei Pei, Qiqi Yang, Yuan Wang, Xiaolei Jin, He Liu, Liang Zhang, Hongwei Ma, Linfeng Cheng, Yangchao Dong, Yingfeng Lei, Yinlan Bai, Zhikai Xu, Pengbo Yu, Fanglin Zhang, Wei Ye   +16 more
doaj   +1 more source