Results 71 to 80 of about 751,858 (288)

Heat waves and human well-being in Madrid (Spain) [PDF]

, 2019
Heat waves pose additional risks to urban spaces because of the additional heat provided by urban heat islands (UHIs) as well as poorer air quality.
Allende, Fernando, Fernández, Felipe, Martilli, Alberto, Rasilla, Domingo   +3 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Measurement and Modeling of Ground-Level Ozone Concentration in Catania, Italy using Biophysical Remote Sensing and GIS [PDF]

, 2017
This experimental study examined spatial variation of ground level ozone (O3) in the city of Catania, Italy using thirty passive samplers deployed in a 500-m grid pattern. Significant spatial variation in ground level O3 concentrations (ranging from 12.8
Brusca, Sebastian, Famoso, Fabio, Lanzafame, Rosario, Lulla, Vijay, Monforte, Pietro, Wilson, Jeffrey   +5 more
core   +1 more source

Determination of the airborne sound insulation of a straw bale partition wall [PDF]

, 2017
This paper describes the results of a scientific project focused on determining of the Airborne Sound Insulation of a peripheral non-load bearing wall made of straw bales expressed by Weighted Sound Reduction Index.
Fabian, Radek, Hrubá, Barbora, Teslík, Jiří   +2 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The effect of short-term changes in air pollution on respiratory and cardiovascular morbidity in Nicosia, Cyprus. [PDF]

, 2007
Presented at the 6th International Conference on Urban Air Quality, Limassol, March, 2007. Short-paper was submitted for peer-review and appears in proceedings of the conference.This study investigates the effect of daily changes in levels of PM10 on the
Demokritou, Philip, Dockery, Douglas W., Kleanthous, Savvas, Kolokotroni, Ourania, Koutrakis, Petros, Middleton, Nicos, Schwartz, Joel D., Yiallouros, Panayiotis K.   +7 more
core   +1 more source

Public Health Relevance of US EPA Air Quality Index Activity Recommendations

JAMA Network Open
ImportanceReducing exposure to fine particulate matter (<2.5 μm [PM2.5]) air pollution improves cardiopulmonary morbidity and mortality. However, the public health relevance of air quality index (AQI) activity guidelines under present-day environmental conditions in the US has not been critically assessed.ObjectiveTo evaluate the public ...
Brook, Robert D., Rajagopalan, Sanjay, Al-Kindi, Sadeer   +2 more
openaire   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Air Quality Legislation in Australia and Canada—A Review

Challenges
Air pollution is a pervasive global issue affecting human health, ecosystems, and the environment. This paper reviews the evolution and implementation of air quality legislation in Australia and Canada, providing a comparative analysis of their ...
Shilpi Tewari, Nidhi Pandey, Jierui Dong
doaj   +1 more source