Results 101 to 110 of about 1,865,989 (385)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

A New Air Quality Index for Cities

, 2011
Global population growth has led to increased populations living in urban areas. Often, this enhances stresses on space, ecosystems, infrastructures, facilities and personal lifestyles. Problems related to quality of life in cities are increasingly relevant, especially with regard to environmental issues.
Silva, Lígia Torres, Mendes, José F. G.   +1 more
openaire   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Hold Your Breath: A New Index of Air Quality [PDF]

Environmental quality and climate change have long attracted attention in policy debates. Recently, air quality has emerged on the policy agenda. We calculate a new index of air quality using CO2and SO2 emissions per capita as indicators and provide a ...
Andreas Buehn, Mohammad Reza Farzanegan
core  

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

Green Price Indices [PDF]

This paper suggests two theoretically consistent and empirically tractable ways that a cost-ofliving index can be expanded to include the environment and other public goods.
Banzhaf, H. Spencer
core  

Mental wellbeing, air pollution and the ecological state [PDF]

, 2019
The ecological State puts environmental considerations at the centre of its actions. To explores its role in the association between air pollution and mental wellbeing, this work employs a hierarchical three-level analysis on the third wave (2011-2012 ...
Bracke, Piet, Buffel, Veerle, Signoretta, Paola E.   +2 more
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

INDEKS KUALITAS AIR PADA KAWASAN TAMBANG BIJIH BESI DI SUB DAS KRUENG IE MIRAH KECAMATAN BABAHROT KABUPATEN ACEH BARAT DAYA [PDF]

, 2018
Sungai merupakan perairan terbuka yang dapat dimanfaatkan serta menampung semua buangan dari kegiatan manusia di daerah pemukiman, pertanian, industri serta pertambangan di daerah sekitarnya.
Quratul Aini
core