Results 101 to 110 of about 3,507,302 (280)

Defining Terminal Airspace Air Traffic Complexity Indicators Based on Air Traffic Controller Tasks

This paper focuses on terminal air traffic complexity indicators. By thorough analysis of previous research, the benefits and limitations of the existing terminal complexity models are identified.
Bruno Antulov-Fantulin, Kristina Samardžić, Tea Jurinić, Biljana Juričić   +3 more
core   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

An Unsupervised Situation Awareness Framework for UAV Sensor Data Fusion Enabled by a Stabilized Deep Variational Autoencoder

Sensors
Effective situation awareness relies on the robust processing of high-dimensional data streams generated by onboard sensors. However, the application of deep generative models to extract features from complex UAV sensor data (e.g., GPS, IMU, and radar ...
Anxin Guo, Zhenxing Zhang, Rennong Yang, Ying Zhang, Liping Hu, Leyan Li   +5 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Dual‐Organelle Secretome Conjugation and Organ‐Uptake Tracking (DuO‐SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins

Advanced Science, EarlyView.
A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Fenglian Yang, Rui Qian, Jiaxing Song, Xingqi Meng, Jin Young Kim, Kwok On Lai, Li Wang, Liang Zhang   +7 more
wiley   +1 more source

Identification of Critical Nodes for Delay Propagation in Susceptible-Exposed-Infected-Recovered (SEIR) and Genetic Algorithm (GA) Route Networks

Aerospace
In response to the challenges associated with forecasting the trajectory of flight delay propagation, pinpointing pivotal nodes within the route network, and the substantial costs involved in enhancing operational efficiency, this study introduces an ...
Mingyu Zhang, Xiangxi Wen, Minggong Wu, Hanchen Xie   +3 more
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

A Method for Air Route Network Planning of Urban Air Mobility

Aerospace
Urban air mobility is an effective solution to address the current issue of ground traffic congestion in future cities. However, as the user scale continues to expand, the current civil aviation flight scheduling and control methods are becoming ...
Jie Li, Di Shen, Fuping Yu, Duo Qi
doaj   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Adaptative air traffic network: Statistical regularities in air traffic management [PDF]

, 2016
Starting from traffic data on flights trajectories-planned and actual ones-in Europe, we build a navigation point network. We study this network which exhibits different features for different European countries. In particular, some countries uses a high number of navpoints, facilitating the planning of the flight plan by air companies at the cost of ...
BONGIORNO, Christian, MICCICHE', Salvatore, MANTEGNA, Rosario Nunzio, Gurtner, G., LILLO, Fabrizio, Pozzi, S.   +5 more
openaire   +1 more source