Results 231 to 240 of about 4,405,851 (347)

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Association of Control Service Types with Aviation Medical Examination Results and Sick Leave in Air Traffic Controllers in Korea. [PDF]

Healthcare (Basel)
Choi JH, Jung HS, Choi EH.
europepmc   +1 more source

Human Factors and Neurophysiological Metrics in Air Traffic Control: A Critical Review

IEEE Reviews in Biomedical Engineering, 2017
P. Aricó, G. Borghini, G. di Flumeri, S. Bonelli, A. Golfetti, I. Graziani, Simone Pozzi, J. Imbert, Géraud Granger, R. Benhacène, D. Schaefer, F. Babiloni   +11 more
semanticscholar   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

An important step forward to address fatigue risk in Federal Aviation Administration air traffic operations. [PDF]

J Clin Sleep Med
Gurubhagavatula I, Rishi MA.
europepmc   +1 more source

Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning

Cytoskeleton, EarlyView.
ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham, Mihir Relan, Matthew T. Swulius, Andrea K. H. Stavoe   +3 more
wiley   +1 more source

Efficient and secure service function chain deployment method for delay optimization in air traffic information network. [PDF]

Sci Rep
Yang Y, Wang B, Guo R, Tian J, Luo P, Li D, Li X.   +6 more
europepmc   +1 more source

Where Tech Meets the SDGs: A Supply‐Chain Process Map for Sustainability Management

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study investigates how advanced technologies support Sustainable Development Goals (SDGs) within supply chain management (SCM) through a structured analysis of 4448 sustainable practices. By integrating perspectives from sustainability‐oriented innovation (SOI) and contingent dynamic capabilities, the research conceptualizes technology ...
Vincenzo Varriale, Antonello Cammarano, Moacir Godinho‐Filho   +2 more
wiley   +1 more source

Rapid Mental Workload Detection of Air Traffic Controllers with Three EEG Sensors. [PDF]

Sensors (Basel)
Li H, Zhu P, Shao Q.
europepmc   +1 more source