Results 71 to 80 of about 73,265 (267)

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Hierarchical Target Tracking for Unmanned Aerial Vehicle Swarms with Distributed Optimization and Affine Control

Drones
Target tracking of unmanned aerial vehicle (UAV) swarms remains a significant challenge due to highly maneuverable target swarms and complex environments.
Han Wang, Xiaolong Liang, Jiaqiang Zhang, Yueqi Hou, Aiwu Yang   +4 more
doaj   +1 more source

Cholesterol‐Mediated Metabolic‐mechanotransductive Crosstalk Orchestrates Castration Resistance in Prostate Cancer

Advanced Science, EarlyView.
Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu, Chao Xu, Jun Jiang, Limin He, Yike Zhou, Zhengxuan Li, Yu Li, Keying Zhang, Fa Yang, Tong Lu, Hongtao Song, Hai Zhu, Zhihao Hu, Xiaolong Zhao, Kai Gan, Hongji Li, Bo Yang, Rui Zhang, Weihong Wen, Donghui Han, Weijun Qin   +20 more
wiley   +1 more source

Deception mechanisms of FDA‒AWACS against passive monopulse angle measurements

IET Radar, Sonar & Navigation
Airborne warning and control systems (AWACS) serve as critical command and control centres in air combat operations, making them prime targets for strategic attacks.
Bo Wang, Gang Wang, Yonglin Li, Rennong Yang, Yu Zhao   +4 more
doaj   +1 more source

Research on Integrated Decision-Control Cooperative Target Assignment for Cross-Domain Unmanned Systems Based on a Bi-Level Optimization Framework

Drones
Addressing prevalent challenges in current cooperative task assignment methods for cross-domain unmanned swarm, such as the disconnection between decision-making and execution processes, and the inadequate incorporation of platform kinematic constraints,
Aoyu Zheng, Xiaolong Liang, Zhiyang Zhang, Yuyan Xiao, Jiaqiang Zhang   +4 more
doaj   +1 more source

Air Traffic Smoothness as a Universal Measure for Air Traffic Quality Assessment

Procedia Engineering, 2016
AbstractAir traffic in European airspace is coordinated centrally by the air traffic flow management services – Network Management Operation Centre (NMOC). Their main task is to compare resources (number and capacity of air traffic control sectors) and needs (size of the planned and actual traffic).
Dmochowski, Piotr Andrzej, Skorupski, Jacek   +1 more
openaire   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Identification Method of Critical Routes in Aviation Network Based on Double Capacity Identification Standard

Hangkong gongcheng jinzhan, 2019
A method of identifying critical routes in the aviation network based on dual capacity identification standard is used for improving the singleness of the traditional identification method and incomplete evaluation index of network performance.
Li Jiawei, Liu Fei, Wu Minggong, Yu Minjian, Kang Runzhe   +4 more
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source