Results 71 to 80 of about 144,156 (294)

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source

A Data-Driven Methodology for Developing a Future Design Day Flight Schedule (DDFS)

Aerospace
The design day flight schedule (DDFS) plays a pivotal role in airport simulation and infrastructure planning. Despite its importance, previous studies and global guidelines offer only broad recommendations for DDFS preparation, lacking detailed ...
Eunji Kim, Seokjae Yun, Hojong Baik
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

TTI Researchers Develop Curriculum for Transportation Emissions and Health [PDF]

Researchers in the Texas A&M Transportation Institute\u2019s (TTI\u2019s) Center for Advancing Research in Transportation Emissions, Energy, and Health (CARTEEH) have developed a cross-disciplinary course titled Traffic-Related Air Pollution: Emissions ...
Texas A&M University, Center for Advancing Research in Transportation Emissions, Energy, and Health. Texas A&M Transportation Institute   +1 more
core   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Cost-benefit analysis : substituting ground transportation for subsidized essential air services. [PDF]

DTRT13-G-UTC37Since the Airline Deregulation Act of 1978, the U.S. Department of Transportation (DOT) has been subsidizing air service tosmall rural communities through the Essential Air Service (EAS) program.
Wood, Abby, Bao, Ken, Mundy, Ray A., University of Missouri--St. Louis. Center for Transportation Studies   +3 more
core  

Recognizing the Potential to Reduce GHG Emissions through Air Transportation Electrification [PDF]

ZSB12017-SJAUXCalifornia is aggressively moving forward with efforts to deploy zero-emission transportation technology to fight climate change, especially the Greenhouse Gas (GHG) emissions from the high-impact transportation sector.
Oldham, Joseph, San Jose State University, Roa, Julio, Mineta Transportation Institute, Lima, Marina   +4 more
core   +1 more source

A Collaborative Route Optimization Model for Regional Multi-Airport System

IEEE Access, 2019
In this paper, the author set up an index system on the airport collaboration of the multi-airport system (MAS), including the number of external routes, the total cost of the route network, the passenger volume of the MAS, the airport primacy ratio, the
Li Zhang, Cheng Li, Kai Xu, Yiqin Yang
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Air transportation under COVID-19 pandemic restrictions: A wavelet analysis. [PDF]

Transp Policy (Oxf), 2023
Mutascu M, Sokic A.
europepmc   +1 more source