Results 291 to 300 of about 941,937 (358)

Aire

Annual Review of Immunology, 2009
Mutations in the transcriptional regulator, Aire, cause APECED, a polyglandular autoimmune disease with monogenic transmission. Animal models of APECED have revealed that Aire plays an important role in T cell tolerance induction in the thymus, mainly by promoting ectopic expression of a large repertoire of transcripts encoding proteins normally ...
Diane Mathis, Christophe Benoist
exaly   +3 more sources

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

Science, 2002
Ludger Klein, Zhibin Chen, Shannon J Turley   +2 more
exaly   +2 more sources

Aire drives steroid hormone biosynthesis by medullary thymic epithelial cells

Science immunology, 2023
Thymic epithelial cells (TECs) produce glucocorticoids, which antagonize negative selection of autoreactive thymocytes and promote a competent T cell antigen–specific repertoire.
Matthew D. Taves, Kaitlynn M. Donahue, Jing Bian, M. Cam, J. Ashwell   +4 more
semanticscholar   +1 more source

A novel AIRE-based fluorescent ratiometric probe with endoplasmic reticulum-targeting ability for detection of hypochlorite and bioimaging.

Bioorganic chemistry (Print), 2022
Hypochlorite (ClO-) plays an important role in the human immune defense system, but high concentrations of ClO- in the endoplasmic reticulum (ER) damage cellular proteins, causing ER stress, cell death, and various diseases. Herein, we developed a simple
Jin-Long Yan, Ling Zhang, Wei-Na Wu, Yuan Wang, Zhiyang Xu   +4 more
semanticscholar   +1 more source

Aire deficiency leads to the development of alopecia areata-like lesions in mice.

Journal of Investigative Dermatology, 2022
Alopecia areata (AA) is an autoimmune hair loss disorder with no cure. Patients with mutations in autoimmune regulator (AIRE) are 15x more likely to develop AA than the general population, yet roles for AIRE in AA pathogenesis are unknown.
N. Maglakelidze, Ting Gao, R. Feehan, R. Hobbs   +3 more
semanticscholar   +1 more source

AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization

Nature
Kushagra Bansal, Sara Mostafavi, Diane Mathis   +2 more
exaly   +2 more sources

Autoimmune regulator (AIRE): Takes a hypoxia‐inducing factor 1A (HIF1A) route to regulate FOXP3 expression in PCOS

American Journal of Reproductive Immunology, 2022
Autoimmune polyendocrinopathy‐candidiasis‐ ectodermal dystrophy (APECED) pathology due to autoimmune regulator (AIRE) gene mutations leads to loss of central tolerance triggering immune attack, a factor causing infertility.
Renjini A. Padmanabhan, Betcy Susan Johnson, Ajay Kumar Dhyani, S. Pillai, K. Jayakrishnan, M. Laloraya   +5 more
semanticscholar   +1 more source

AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies

Cell, 2016
Summary APS1/APECED patients are defined by defects in the autoimmune regulator (AIRE) that mediates central T cell tolerance to many self-antigens. AIRE deficiency also affects B cell tolerance, but this is incompletely understood.
Jaanika Kärner, Dmytro Fishman, Hedi Peterson   +2 more
exaly   +2 more sources

AIRE expands: new roles in immune tolerance and beyond

Nature Reviews Immunology, 2016
Maureen A Su
exaly   +2 more sources

Aire in Autoimmunity

Annual Review of Immunology
The role of the autoimmune regulator (Aire) in central immune tolerance and thymic self-representation was first described more than 20 years ago, but fascinating new insights into its biology continue to emerge, particularly in the era of advanced ...
Corey N. Miller, M. Waterfield, J. Gardner, Mark S. Anderson   +3 more
semanticscholar   +1 more source