Results 191 to 200 of about 9,481,015 (253)

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Intelligent Perception, Decision-Making and Actuation Technologies for Precision Agrochemical Spraying: Current Advances and Future Perspectives. [PDF]

Sensors (Basel)
Song Q, Zhang F, Ma Z, Cui B, Wang C.
europepmc   +1 more source

Expanding Metabolic Online Monitoring Capabilities in 96‐Deepwell Microtiter Plates by Combining Optoelectronic O2 and CO2 Sensors

Biotechnology and Bioengineering, EarlyView.
ABSTRACT To increase the information content in early stages of bioprocess development, various technologies have been introduced for monitoring cultivations in microtiter plates (MTPs). Besides spectroscopical measurements, like in the BioLector technology, optical measurements with luminescent sensors, placed directly in the cultivation medium ...
Robert Dinger, David Pfeifer, David Flitsch, Jan P. Fischer, Clemens Lattermann, Sergey M. Borisov, Jochen Büchs   +6 more
wiley   +1 more source

The silent zone of paediatric asthma: integrating small airway dysfunction assessment into clinical practice. [PDF]

EClinicalMedicine
Indolfi C, Klain A, Dinardo G, Grella C, Cascone S, Miraglia Del Giudice M.   +5 more
europepmc   +1 more source

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source

Is full inhalation during spirometry inhibited by COPD pathophysiology? [PDF]

ERJ Open Res
Dean J, Dean A, Beech A, Singh D.
europepmc   +1 more source

Anatomy of the Soft Palate and Its Role in Upper Airway Function: A Narrative Review

Clinical Anatomy, EarlyView.
ABSTRACT The soft palate is a complex anatomical structure, located at the posterior aspect of the oral and nasal cavities, able to dynamically create valve closure of the nasal and the oral cavities. Its precise movement is critical for speech, swallowing, and respiration. Despite its functional importance, detailed characterization of its constituent
James C. D. Miller, Nikki Mills, Ho‐Fung Chan, Alys R. Clark, S. Ali Mirjalili   +4 more
wiley   +1 more source

Identifying Biomarkers for Chronic Obstructive Pulmonary Disease in the Salivary Metabolome. [PDF]

Int J Chron Obstruct Pulmon Dis
Asandei D, O'Shea K, Paes de Araujo R, Mironas A, Da Costa R, Asibey-Berko T, Ghosh S, Lu C, O'Rourke S, Mur LAJ, Lewis KE.   +10 more
europepmc   +1 more source

Waste Sawdust‐Derived Hard Carbon Anodes With Engineered Interlayer Spacing for Sodium‐Ion Batteries Exhibiting High Initial Coulombic Efficiency

Carbon Energy, EarlyView.
It is demonstrated that waste sawdust, a green, eco‐friendly, and low‐cost biomass byproduct, can be converted into high‐performance hard carbon through the application of a precisely controlled heating rate. This strategy is optimized and validated through first‐principles calculations, achieving precise control over interlayer spacing and pore ...
Jie Di, Pengcheng Mao, Xiang Li, Yuqi Liu, Jingyi Luan, Wenbin Hu, Cheng Zhong   +6 more
wiley   +1 more source

Volumetric Thermal Characterisation of a Controlled Bioprinting Chamber Using Multi-Point Temperature Sensing. [PDF]

Biomimetics (Basel)
Marcos-Romero AC, Matamoros-Pacheco M, Mendoza-Cerezo L, Díaz-Prado SM, Rodríguez-Rego JM.   +4 more
europepmc   +1 more source