Results 141 to 150 of about 1,180,011 (399)

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen

Respiratory Research
Background Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in ...
Melissa A. Kovach, Ulrika Käck, Karlhans F Che, Bettina Brundin, Jon R. Konradsen, Anders Lindén   +5 more
doaj   +1 more source

Effects of Long-acting Muscarinic Antagonists on Promoting Ciliary Function in Airway Epithelium

, 2021
Mineo Katsumata, Tomoyuki Fujisawa, Yosuke Kamiya, Yūko Tanaka, Chiaki Kamiya, Yusuke Inoue, Hironao Hozumi, Masato Karayama, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Masato Maekawa, Mitsutoshi Setou, Hiroshi Watanabe, Koji Ikegami, Takafumi Suda   +17 more
openalex   +1 more source

Interior Decorative VOCs Elevate T Cell‐Mediated Obstructive Lung Disease Risks via Osteogenesis‐Driven Lymphoid‐Biased Hematopoiesis

Advanced Science, EarlyView.
This study utilizes a whole‐body inhalation model to reveal that interior decorative VOCs exposure persistently elevates alveolar T cells. This increase is attributed to lymphoid‐biased hematopoiesis in the bone marrow, which is further driven by IL‐6/IL‐17A‐mediated osteogenic differentiation.
Hongyan Yu, Jingxu Zhang, Qingping Liu, Duxing Li, Ruonan Pan, Gan Miao, Yidi Chen, Zhe Kou, Guangbo Qu, Rong Zhang, Xiaoting Jin, Yuxin Zheng   +11 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

S9 Cluster Analysis Reveals a Distinct Small Airway-Predominant Phenotype of Asthma [PDF]

, 2012
Sherif Gonem, Sushiladevi Natarajan, Ruth Hartley, Sumit Gupta, Dhananjay Desai, Steven Corkill, Amisha Singapuri, Peter Bradding, Per Gustafsson, Christopher E. Brightling, Salman Siddiqui   +10 more
openalex   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source

Artificial Intelligence‐Driven Soft Bioelectronics for Self‐Powered Respiration Monitoring

Advanced Science, EarlyView.
Artificial intelligence‐driven soft bioelectronics for self powered respiration monitoring based on triboelectric nanogenerators (TENGs), piezoelectric nanogenerators (PENGs), and magnetoelastic generators (MEGs) enable continuous and multi‐scenario respiratory biomechanical data collection. Coupled with machine learning and big data driven diagnostics,
Xinkai Xu, Xiao Xiao, Rui Guo, Jun Chen
wiley   +1 more source

Imaging of human airways by endoscope-compatible dynamic microscopic optical coherence tomography

Frontiers in Medicine
IntroductionMicroscopy is a cornerstone for diagnostics in lung disease but was traditionally restricted to biopsies and explanted tissue. Microscopic optical coherence tomography (mOCT) produces images with microscopic resolution without the need for ...
Cornelia Holzhausen, Cornelia Holzhausen, Hinnerk Schulz-Hildebrandt, Hinnerk Schulz-Hildebrandt, Hinnerk Schulz-Hildebrandt, Martin Ahrens, Martin Ahrens, Noah Heldt, Noah Heldt, Mario Pieper, Mario Pieper, Heike Biller, Heike Biller, Sönke von Weihe, Sönke von Weihe, David Ellebrecht, David Ellebrecht, Mustafa Abdo, Mustafa Abdo, Stefan Steurer, Christoph Fraune, Klaus F. Rabe, Klaus F. Rabe, Gereon Hüttmann, Gereon Hüttmann, Peter König, Peter König   +26 more
doaj   +1 more source

The nature of small-airway obstruction in chronic obstructive pulmonary disease.

New England Journal of Medicine, 2004
J. Hogg, F. Chu, Soraya Utokaparch, R. Woods, W. Elliott, L. Buzatu, R. Cherniack, R. Rogers, F. Sciurba, H. Coxson, P. Paré   +10 more
semanticscholar   +1 more source