Results 121 to 130 of about 39,928 (244)

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, Volume 183, Issue 11, Page 2660-2674, June 2026.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma. [PDF]

, 2009
The innate immune response of airway epithelial cells to airborne allergens initiates the development of T cell responses that are central to allergic inflammation.
Angkasekwinai, Pornpimon, Barranco, Wade T, Corry, David B, Dong, Chen, Goswami, Sangeeta, Greenlee, Kendra J, Kheradmand, Farrah, Polikepahad, Sumanth, Redding, David, Seryshev, Alexander, Shan, Ming, Singh, Bhupinder, Song, Li-zhen, Sur, Sanjiv, Woodruff, Prescott   +14 more
core  

Are Phenotypic Baseline Characteristics Related to Abolition of AHR After Benralizumab and Dupilumab?

Clinical &Experimental Allergy, EarlyView.
Philipp Suter, Robert Greig, Rory Chan, Brian J. Lipworth   +3 more
wiley   +1 more source

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

American Journal of Hematology, Volume 101, Issue 5, Page 961-971, May 2026.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St‐Laurent, Estelle Lecluze, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez   +10 more
wiley   +1 more source

Asthma: where is it going?

Brazilian Journal of Medical and Biological Research
Asthma is characterized by reversible airway obstruction, airway hyperresponsiveness, and airway inflammation. Although our understanding of its pathophysiological mechanisms continues to evolve, the relative contributions of airway hyperresponsiveness ...
D.S. Faffe
doaj   +1 more source

Tezepelumab Reduces Alarmin Cytokine Levels in Upper Airway Epithelial Cells in Patients With Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Hazel Marriott, Adil Adatia, Subhabrata Moitra, Paige Lacy   +3 more
wiley   +1 more source

Sustainable Applications of Thymol: Advances in Formulation Technologies, Drug Delivery Systems, and Food Preservation Strategies

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Thymol is a natural monoterpene with antimicrobial, antioxidant, anti‐inflammatory, and anticancer activities relevant to food and biomedical applications. Its poor solubility and instability can be improved through nanodelivery systems. Thymol also supports sustainable food preservation and active packaging, although further clinical validation and ...
Farhang Hameed Awlqadr, Mohammed N. Saeed, Ammar B. Altemimi, Syamand Ahmed Qadir, Aryan Mahmood Faraj, Othman Abdulrahman Mohammed, Tablo H. Salih, Rawaa H. Tlay, Tarek Gamal Abedelmaksoud   +8 more
wiley   +1 more source

Functional Endoscopic Sinus Surgery in Adults With CRSwNP Treated With Mepolizumab: Airway Physiology Outcomes From a Randomised Controlled Trial

Clinical &Experimental Allergy, EarlyView.
Jens Tidemandsen, Anne Sophie Homøe, Peter G. Gibson, Howraman Meteran, Kasper Aanæs, Morten Hostrup, Marie Høxbro, Vibeke Backer   +7 more
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, Volume 46, Issue 3, Page 672-712, May 2026.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Targeting Hyperoxia‐Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

Aging Cell, Volume 25, Issue 5, May 2026.
Supplemental oxygen is critical for premature infants. While initially beneficial, even moderate hyperoxia (< 60% O2) induces detrimental cellular senescence in developing airways with long‐lasting consequences. Senotherapeutics such as Fucoidan, Dasatinib (D) + Quercetin (D + Q), and mitochondrial‐targeted antioxidant MitoQ may be beneficial in ...
Maunick Lefin Koloko Ngassie, Li Y. Drake, Yi Zhu, Yamillie Ortiz, Daniel A. Pfeffer‐Kleemann, Michael A. Thompson, Samantha K. Hamrick, Christina M. Pabelick, Y. S. Prakash   +8 more
wiley   +1 more source