Results 191 to 200 of about 39,928 (244)
Some of the next articles are maybe not open access.
Chest, 2003
Airway hyperresponsiveness is a characteristic feature of asthma and consists of an increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist. Measurements of airway responsiveness are useful in making a diagnosis of asthma, particularly in patients ...
Paul M, O'Byrne, Mark D, Inman
openaire +2 more sources
Airway hyperresponsiveness is a characteristic feature of asthma and consists of an increased sensitivity of the airways to an inhaled constrictor agonist, a steeper slope of the dose-response curve, and a greater maximal response to the agonist. Measurements of airway responsiveness are useful in making a diagnosis of asthma, particularly in patients ...
Paul M, O'Byrne, Mark D, Inman
openaire +2 more sources
Asthma And Airway Hyperresponsiveness
Annual Review of Medicine, 1991Airway hyperresponsiveness to a large number of stimuli is a characteristic of asthma in humans. Various components of the tracheobronchial tree might contribute to this characteristic, such as smooth muscle, the bronchial epithelium, various neurohumoral mechanisms, and the mechanical linkages between the lung parenchyma and the airways. The degree of
openaire +2 more sources
Genetics of airway hyperresponsiveness
Journal of Allergy and Clinical Immunology, 2001Asthma is a disease characterized by intermittent airway obstruction, inflammatory cell infiltrates, increased mucus production, lung epithelial remodeling, and airway hyperreactivity. The genetics of asthma, as investigated in animal models, is poorly understood. Because no animal model of asthma mimics all of the pathologic and physiological features
G T, De Sanctis, M, Daheshia, A, Daser
openaire +2 more sources
Sulfuric Acid-Induced Airway Hyperresponsiveness
Toxicological Sciences, 1986Rabbits were exposed to submicrometer sulfuric acid (H2SO4) mist at 250 micrograms/m3 for 1 hr/day, 5 days/week for 4, 8, or 12 months in order to examine the effects on bronchial responsiveness, which was assessed at the end of each exposure series by administration (iv) of doubling doses of acetylcholine and measurement of pulmonary resistance (RL ...
J M, Gearhart, R B, Schlesinger
openaire +2 more sources
Airway hyperresponsiveness: First eosinophils and then neuropeptides
International Journal of Immunopharmacology, 1997Airway hyperreactivity to bronchoconstrictor mediators is a main characteristic in the majority of asthmatic patients and correlates well with the severity of the disease. The airways of asthmatic patients are characterized by an inflammatory state resulting in activation of lung tissue cells and attraction and infiltration of leukocytes from the blood.
Kraneveld, A D +3 more
openaire +3 more sources
The origin of airway hyperresponsiveness
Journal of Allergy and Clinical Immunology, 1986Consideration of the origin of airway hyperresponsiveness appears central to understanding the origin of asthma. Subjects with and without asthma differ both in the ease with which airway narrowing is produced by inhalation of histamine or methacholine and in the ability to demonstrate a maximal response to these agents.
Hargreave, Frederick E. +4 more
openaire +3 more sources
Mechanical Determinants of Airways Hyperresponsiveness
Critical Reviews™ in Biomedical Engineering, 2011Asthmatic individuals typically experience exaggerated decrements in their ability to breathe after receiving standardized doses of smooth muscle agonist, a phenomenon known as airways hyperresponsiveness (AHR). Breathing difficulties are caused by excessive narrowing of the pulmonary airways, which is instigated by shortening of the airway smooth ...
Jason H T, Bates, Geoffrey N, Maksym
openaire +2 more sources
Potential Mechanism of Hyperresponsive Airways
American Journal of Respiratory and Critical Care Medicine, 2000It has been known for many years that the response of asthmatic subjects to a deep inspiration differs from that observed in normal healthy subjects. A deep inspiration causes a decrease in airway resistance in normal subjects, whereas asthmatics demonstrate either no change or a slight increase in airway resistance.
W, Mitzner, R H, Brown
openaire +2 more sources
Physiopathology of airway hyperresponsiveness
Current Allergy and Asthma Reports, 2003Airway hyperresponsiveness (AHR), the tendency of the airways to narrow too much and too easily in response to various stimuli, is a universal feature of asthma, although it is not exclusive to this disease. Airway responsiveness shows a unimodal distribution in the general population and might vary with time, increasing after exposure to allergens ...
openaire +2 more sources
Airway Hyperresponsiveness in Elite Athletes
American Journal of Respiratory and Critical Care Medicine, 2000It has been suggested that high-level training could contribute to the development of airway hyperresponsiveness (AHR), but the comparative effects of different sports on airway function remains to be determined. We evaluated 150 nonsmoking volunteers 18 to 55 yr of age; 100 athletes divided into four subgroups of 25 subjects each according to the ...
J B, Langdeau +5 more
openaire +2 more sources