Results 81 to 90 of about 11,942,050 (297)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Three-Airy Beams, Their Propagation in the Fresnel Zone, the Autofocusing Plane Location, as Well as Generalizing Beams

Photonics
A family of 2D light fields consisting of the product of three Airy functions with linear arguments has been studied theoretically and experimentally.
Eugeny G. Abramochkin, Svetlana N. Khonina, Roman V. Skidanov   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Naprężenia w Trójprzegubowym Łuku Tarczowym

Engineering Transactions, 1958
The plane state of stress is considered for symmetric plate arches used as bridge structures. The Airy function determining the stresses in the arches is assumed in the form of a series obtained by separating variables in polar coordinates.
K. Wysiatycki
doaj  

Subleading analysis for S 3 partition functions of N $$ \mathcal{N} $$ = 2 holographic SCFTs

Journal of High Energy Physics
We investigate the 3-sphere partition functions of various 3d N $$ \mathcal{N} $$ = 2 holographic SCFTs arising from the N stack of M2-branes in the ’t Hooft limit both analytically and numerically.
Seppe Geukens, Junho Hong
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A Cauchy like problem in plane elasticity

Vietnam Journal of Mechanics, 2007
Let \(\Omega \) be a bounded domain in the plane, representing an elastic body. Let \(\Gamma_0 \) be a portion of the boundary \(\Gamma\) of \(\Omega \), \(\Gamma_0 \) being assumed to be paralled to the \(x\)-axis. It is proposed to determine the stress
Dang Dinh Ang, Nguyen Dung
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A Fourier transform differentiator operator

Results in Physics
By utilizing the Fourier transform, we present a practical method for evaluating a function of a derivative applied to any other arbitrary function of a single complex variable.
Blanca L. Moreno-Ley, Jorge A. Anaya-Contreras, Arturo Zúñiga-Segundo, Héctor M. Moya-Cessa   +3 more
doaj   +1 more source