Results 51 to 60 of about 16,245 (215)

Impact of C18 Epimerization of Indole‐ and Pyrazole‐Fused 18β‐Glycyrrhetinic Acid Derivatives on PTP1B and TCPTP Inhibitory Activity: Synthesis, In Vitro, and In Silico Studies

open access: yesChemMedChem, Volume 20, Issue 22, November 18, 2025.
The indole derivative (FC‐114) and the N‐phenylpyrazole (FC‐122) of glycyrrhetinic acid are both potent inhibitors of the Protein Tyrosine Phosphatase 1B, with IC50 values of 0.48 μM and 1.15 μM, respectively. However, their activity decreases by up to four times when the 18β‐H position is epimerized to 18α‐H or when the carbonyl group at the C11 ...
Ledy De‐la‐Cruz‐Martínez   +10 more
wiley   +1 more source

La oxitocina intranasal afecta la respuesta de estrés al aislamiento social en ovejas [PDF]

open access: yes, 2021
La oxitocina (OT) es una hormona neuropéptídica que modula varios comportamientos sociales y puede afectar la respuesta de ansiedad y estrés. El objetivo de este estudio fue determinar si la administración de OT intranasal afecta la respuesta de estrés ...

core  

Fatiga laboral en personas que realizaron trabajo en casa en tiempos de confinamiento por COVID-19

open access: yesUniversidad y Salud, 2021
Introducción: El aislamiento social por Covid-19 llevó a muchos colaboradores a realizar trabajo en casa y asimismo a experimentar diversas sensaciones que conjugadas con factores laborales, demandas físicas, emocionales y/o mentales, presentaron fatiga ...
Doris Amparo Barreto-Osma   +2 more
doaj   +1 more source

Escribir en comunidad: Construcción de relaciones y responsabilidad en la producción de conocimiento

open access: yesAmerican Anthropologist, Volume 127, Issue 3, Page 447-465, September 2025.
ABSTRACT As anthropology reckons with its past, present, and future, anthropologists increasingly seek to challenge inequities within the discipline and academia more broadly. Anthropology, regardless of subdiscipline, is a social endeavor. Yet research often remains an isolating (though not necessarily solitary) process, even within research teams and
Jordi Armani Rivera Prince   +16 more
wiley   +1 more source

La soledad y el aislamiento social en las personas mayores

open access: yes, 2020
El aislamiento social se define como una ausencia objetiva de relaciones/contactos sociales y la soledad como la experiencia subjetiva aversiva que se siente al valorar esas relaciones/contactos sociales como insuficiente en cantidad y/o calidad. Existen
Vicente Arruebarrena, Aitor   +1 more
core   +1 more source

Implementation of a Biologically Inspired Responsive Joint Attention System for a Social Robot

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 6, June 2025.
This work introduces a responsive joint attention system in the social robot Mini, enabling dynamic, human‐like responses based on the user's head, body, and gaze. The system enhances user engagement and robot responsiveness. An experiment reveals significant improvements in social presence when the system is active, validating its effectiveness in ...
Jesús García‐Martínez   +4 more
wiley   +1 more source

Impacto social de las medidas de aislamiento obligatorio por COVID19 en el AMBA : informe de avance

open access: yes, 2020
En esta ocasión, el ODSA presenta un conjunto de estudios analítico-descriptivos en donde se da cuenta de algunos de los efectos socioeconómicos, psicosociales y políticociudadanos que han generado las políticas económico-sanitarias en contexto del ...
Salvia, Agustín, Poy, Santiago
core  

TÉCNICAS DE ARTETERAPIA EN CASA COMO CUIDADO DE ENFERMERÍA PARA ADULTOS MAYORES EN CONTINGENCIA POR COVID-19

open access: yesCogitare Enfermagem, 2020
Objective: to present a brief description of home art therapy techniques as Nursing care for older adults in contingency due to COVID-19. Development: faced with the pronouncement of the health measures for COVID-19, older adults as the highest risk ...
Sergio Albañil-Delgado   +2 more
doaj   +1 more source

Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis

open access: yesVeterinary Dermatology, Volume 36, Issue 3, Page 302-313, June 2025.
Background – Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several
Costanza Spadini   +11 more
wiley   +1 more source

Home - About - Disclaimer - Privacy