Results 111 to 120 of about 1,029,273 (252)

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Reactive self-consumption strategy to suppress SiO2 phase transition-induced cracking

Journal of Advanced Ceramics
The lifetime of Si bond coats in environmental barrier coatings (EBCs) is constrained by phase transition-induced cracking at the SiO₂ scale. In this study, reactive self-consumption and lattice solid solution strategies are employed to address this ...
Lin Chen, Shu-Wen Li, Chang-Jiu Li, Qiang Zhang, Guan-Jun Yang   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Formulation of geopolymer coating spray and its antifungal activity

Journal of King Saud University: Engineering Sciences
This study aimed to develop an antifungal coating using a geopolymer in combination with zinc oxide nano- particles (ZnONPs). The coating spray was formulated by adjusting the Si/Al ratio, while maintaining a constant Na/Al ratio. This study assessed the
Pattarasuda Viensiri, Chalermphan Narattha, Suthee Wattanasiriwech, Darunee Wattanasiriwech, Putarak Chomnunti, Witaya Shongkittikul, Anucha Wannagon   +6 more
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Interaction and evolution of phases at the coating/substrate interface in galvannealed 3rd Gen AHSS with high Si content

Materials & Design
Optimization of the galvannealing for cutting-edge 3rd generation AHSS requires detailed structural and chemical characterization. Alloying elements such as Si dramatically modify the steel surface, forming an oxide layer during pre-annealing, which ...
Alexey Minenkov, Martin Arndt, Johannes Knapp, Günter Hesser, Christian Gierl-Mayer, Thomas Mörtlbauer, Gerhard Angeli, Heiko Groiss   +7 more
doaj   +1 more source

State of Strain and Development of Microstructure of 22MnB5 Steel and Al-Si Coating During Deep Drawing of Automotive B Pillar

Archives of Metallurgy and Materials, 2023

semanticscholar   +1 more source