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Hematology/Oncology Clinics of North America, 2020
This article focuses on the patient experience of AL amyloidosis; the unique challenges that patients face from the journey to diagnosis through treatment; and management of this complex multisystemic disease. Included are descriptions of the most significant AL amyloidosis symptoms as well as addressing burden of disease, including financial concerns,
Mackenzie Boedicker, Isabelle Lousada
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This article focuses on the patient experience of AL amyloidosis; the unique challenges that patients face from the journey to diagnosis through treatment; and management of this complex multisystemic disease. Included are descriptions of the most significant AL amyloidosis symptoms as well as addressing burden of disease, including financial concerns,
Mackenzie Boedicker, Isabelle Lousada
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Immunomodulatory drugs in AL amyloidosis
Critical Reviews in Oncology/Hematology, 2016Immunoglobulin light chain amyloidosis (AL amyloidosis) is indeed a rare plasma cell disorder, yet the most common of the systemic amyloidoses. The choice of adequate treatment modality is complicated and depends dominantly on the risk stratification of these fragile patients.
Zuzana Kufova +2 more
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Immune mechanisms of AL amyloidosis
Drug Discovery Today: Disease Mechanisms, 2004Light chain amyloidosis (AL) is both a disorder of protein conformation and a plasma cell dyscrasia, with secretion of altered light chains that polymerize systemically into amyloid fibrils leading to organ failure. Knowledge of the biological features of amyloid cells and of the mechanisms determining light chain organ targeting and cytotoxicity is ...
Perfetti V +2 more
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Amyloidosis of pancreatic islets in primary amyloidosis (AL type)
Pathology International, 2005Seven cases of primary amyloidosis (AL‐type) were studied immunocytochemically for the possible involvement of pancreatic islets. The two cases with extensive organ involvement by AL‐amyloidosis revealed amyloid deposits in pancreatic islets by routine HE and Congo red staining, which were positive for amyloid p and amyloid a, but were only focally ...
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