Results 341 to 350 of about 897,077 (404)

Alpha and Omega Classification of β-Lactamase/Transpeptidase-like Superfamily Proteins Based on the Comparison of Their Structural Catalytic Cores. [PDF]

Molecules
Denesyuk AI, Denessiouk K, Johnson MS, Uversky VN.   +3 more
europepmc   +1 more source

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Structural characterization reveals substrate recognition by the taurine transporter TauT. [PDF]

Cell Discov
Xu H, Bai Q, Wang H, Zhao J, Guo A, Li R, Chen Q, Wei Y, Li N, Huang Z, Zhao Y.   +10 more
europepmc   +1 more source

High‐Throughput MicroED for Probing Ion Channel Dynamics

Advanced Science, EarlyView.
High‐throughput MicroED offers a new approach for visualizing ion channel dynamics. This approach reveals NaK’s sodium binding modes and NaK2CNG’s potassium‐induced selectivity filter dilation and gating. By capturing these distinct structures, this work challenges traditional models of ion channel permeation and selectivity. Abstract Ion channels play
Marc J Gallenito, Max TB Clabbers, Jieye Lin, Johan Hattne, Tamir Gonen   +4 more
wiley   +1 more source

Chitinase 3-like protein 1: a diagnostic biomarker for early liver fibrosis in autoimmune liver diseases. [PDF]

Front Immunol
Liu S, Peng C, Xia S, Li C, Dai X, Liu X, Zhang M, Li X, Tang L.   +8 more
europepmc   +1 more source

Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy

Advanced Science, EarlyView.
This study employs neutrophils for the precise delivery of anti‐CD47 antibodies, combined with bacterial outer membrane vesicles, to enhance macrophage phagocytic function in the tumor microenvironment. This approach effectively activates T‐cell anti‐tumor immune responses and significantly reduces the risk of postoperative tumor recurrence and ...
Meng Guan, Xiao‐Ting Xie, Dong Zhou, Kai Cheng, Bin Zhang, Xin‐Yue Xu, Yong Li, Yi‐Tong Zhou, Wei Peng, Li‐Li Chen, Peng‐Shuo Dong, Si Chen, Jia‐Hua Zou, Bo Liu, Yuan‐Di Zhao, Jin‐Xuan Fan   +15 more
wiley   +1 more source

Biosynthesis of a Novel Diketopiperazine Aspkyncin Incorporating a Kynurenine Unit from <i>Aspergillus aculeatus</i>. [PDF]

J Fungi (Basel)
Kong D, Wang X, Liu L.
europepmc   +1 more source

Confinement‐Induced Metastable Supramolecular Assembly: Dynamic Built‐in Electric Field Driving Deep Mineralization of Organic Pollutants

Advanced Science, EarlyView.
Utilizing the 2D confined space of layered double hydroxide (LDH), living supramolecular assembly (LSA) are successfully prepared with smaller intermolecular distances than in crystals. The IEF enhancement value can reach 11.8 times, which induces a charge separation efficiency of 71.52%.
Xiaoqing Cao, Kaixiang Liang, Feifei Peng, Xianggui Kong, Wenying Shi   +4 more
wiley   +1 more source

A narrative review of metabolomics approaches in identifying biomarkers of doxorubicin-induced cardiotoxicity. [PDF]

Metabolomics
Singh A, Bakhtyar M, Jun SR, Boerma M, Lan RS, Su LJ, Makhoul S, Hsu PC.   +7 more
europepmc   +1 more source

Moisture Harvesting by the Structure Regulation of Hygroscopic Hydrogel for Energy and Water Sustainability

Advanced Electronic Materials, EarlyView.
Hygroscopic hydrogels are capable of utilizing the moisture from air, which can transfer the gaseous water to liquid by a surface phase transition. Taking advantage of this water, sustainable water production, thermal management, and electricity generation can be realized.
Yujie Du, Yongliang Zheng, Hong Liu, Shujing Zhao, Xiaomian Wang, Lin Yang   +5 more
wiley   +1 more source