Results 231 to 240 of about 35,646 (256)
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Xenobiotica, 1992
1. The metabolism of albendazole (ABZ), albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO2) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. 2. None of the compounds was metabolically changed by incubation with abomasal fluids of sheep and cattle. 3.
B. Nare +3 more
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1. The metabolism of albendazole (ABZ), albendazole sulphoxide (ABZSO) and albendazole sulphone (ABZSO2) by ruminal, abomasal and ileal fluids of sheep and cattle was investigated under anaerobic conditions in vitro. 2. None of the compounds was metabolically changed by incubation with abomasal fluids of sheep and cattle. 3.
B. Nare +3 more
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Veterinary Parasitology, 2000
The pattern of in vivo uptake of albendazole (ABZ) and its major metabolite, ABZ-sulphoxide (ABZSO), by Haemonchus contortus and Fasciola hepatica recovered from ABZ-treated sheep, was investigated. Concentration profiles of both compounds were simultaneously measured in target tissues/fluids from the same infected sheep. In addition, the proportion of
F. Imperiale +4 more
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The pattern of in vivo uptake of albendazole (ABZ) and its major metabolite, ABZ-sulphoxide (ABZSO), by Haemonchus contortus and Fasciola hepatica recovered from ABZ-treated sheep, was investigated. Concentration profiles of both compounds were simultaneously measured in target tissues/fluids from the same infected sheep. In addition, the proportion of
F. Imperiale +4 more
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Albendazole Therapy for Neurocysticercosis
Archives of Neurology, 1990To the Editor. —I have read with interest the article by Alarcon et al, 1 as it showed that the length of albendazole therapy for parenchymal brain cysticercosis could be considerably shortened without lessening its efficacy. The authors did not state, however, how the 3-day course of albendazole treatment was chosen.
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Toxicology and Applied Pharmacology, 1991
Micromass cell culture systems for rat embryo midbrain (CNS) and limb bud (LB) cells were employed to assess the in vitro developmental toxicity of the human and veterinary anthelmintic albendazole (ABZ) and its sulfoxide metabolite (SOABZ). ABZ is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative.
Elaine M. Faustman, Stephen G. Whittaker
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Micromass cell culture systems for rat embryo midbrain (CNS) and limb bud (LB) cells were employed to assess the in vitro developmental toxicity of the human and veterinary anthelmintic albendazole (ABZ) and its sulfoxide metabolite (SOABZ). ABZ is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative.
Elaine M. Faustman, Stephen G. Whittaker
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Journal of Chromatography B: Biomedical Sciences and Applications, 1991
A sensitive and selective reversed-phase high-performance liquid chromatographic method for the determination of albendazole and its active metabolite albendazole sulphoxide in plasma has been developed. It involves single-step extraction of plasma with dichloromethane, evaporation of the solvent and chromatography on a muBondapak phenyl column with a ...
Stephen A. Ward +6 more
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A sensitive and selective reversed-phase high-performance liquid chromatographic method for the determination of albendazole and its active metabolite albendazole sulphoxide in plasma has been developed. It involves single-step extraction of plasma with dichloromethane, evaporation of the solvent and chromatography on a muBondapak phenyl column with a ...
Stephen A. Ward +6 more
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Research in Veterinary Science, 2009
The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54h post-treatment and
G. Castells +6 more
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The kinetics of albendazole metabolites and albendazole sulphoxide enantiomers were studied in 2- and 14-month-old female and male goats, after a single oral dose administration (10mg/kg) of an albendazole formulation. Blood samples from the jugular vein were collected at 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 30, 36, 42, 48 and 54h post-treatment and
G. Castells +6 more
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Albendazole for the treatment of echinococcosis
Fundamental & Clinical Pharmacology, 2003AbstractTwenty years after the first cases of echinococcal disease were treated with albendazole, it has become an important component in the overall management of both cystic and alveolar echinococcosis. This paper reviews some of the key steps and issues facing those who work in clinical research and who deal on a day‐to‐day basis with echinococcal ...
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International Journal for Parasitology, 1994
Protoscoleces of Echinococcus granulosus were incubated in vitro with decreasing concentrations of either albendazole (ABZ) or albendazole sulphoxide (ABZ.SO) (50, 10, 1 and 0.1 micrograms ml-1), and in combination. Viability was assessed by the methylene blue exclusion test and establishment of infection in mice.
Guillermo +4 more
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Protoscoleces of Echinococcus granulosus were incubated in vitro with decreasing concentrations of either albendazole (ABZ) or albendazole sulphoxide (ABZ.SO) (50, 10, 1 and 0.1 micrograms ml-1), and in combination. Viability was assessed by the methylene blue exclusion test and establishment of infection in mice.
Guillermo +4 more
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Neurocysticercosis: treatment with albendazole and dextrochloropheniramine
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1989We evaluated the use of albendazole in combination with dextrochloropheniramine for the treatment of neurocysticercosis. Forty patients were treated from September 1984 to December 1987; each was diagnosed on the basis of clinical, epidemiological, cerebrospinal fluid and tomographic data.
Agapejev, S. +7 more
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Albendazole therapy for neurocysticercosis
Neurology, 1998Reply from the Authors: The need for placebo-controlled studies in the treatment of neurocysticercosis (NCC) was commented on soon after the introduction of praziquantel as the first antiparasitic drug for this condition.16 Double-blind randomized trials including an untreated placebo group were not instituted because such a study was considered ...
Robert H. Gilman +3 more
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