Results 111 to 120 of about 21,367 (237)

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, Volume 92, Issue 4, Page 1058-1068, April 2026.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Why we age

Biological Reviews, Volume 101, Issue 2, Page 911-925, April 2026.
ABSTRACT Three categories of explanations exist for why we age: mechanistic theories, which omit reference to evolutionary forces; weakening force of selection theories, which posit that barriers exist that prevent evolutionary forces from optimising fitness in ageing; and optimisation theories, which posit that evolutionary forces actually select for ...
Michael S. Ringel
wiley   +1 more source

How common is albinism really? Colour aberrations in Indian birds reviewed [PDF]

, 2016
The file attached is the Published/publisher’s pdf version of the ...
Mahabal, A, Sharma, RM, Thakur, S, Van Grouw, H   +3 more
core  

pH‐Dependent Microenvironmental Ionic Signaling in Pancreatic Ductal Adenocarcinoma

Acta Physiologica, Volume 242, Issue 4, April 2026.
ABSTRACT Aim Pancreatic ductal adenocarcinoma (PDAC) develops within a uniquely dynamic pH landscape shaped by substantial acid–base fluxes produced by the exocrine pancreas. Secretion of alkaline pancreatic juice, normally linked to digestion, produces intermittent acidifications of the pancreatic interstitium, which challenges epithelial and stromal ...
Albrecht Schwab, Micol Rugi, Pawel Swietach, Wiktoria Błaszczak, Ivana Novak, Ganga Deshar, Stine Falsig Pedersen, Renata Ialchina, Albin Sandelin, Jiayi Yao, Stephan J. Reshkin, Rosa A. Cardone, Tiago M. A. Carvalho, Annarosa Arcangeli, Rayhana Bouazzi, Franco N. D'Alessandro, Natalia Prevarskaya, Madelaine M. Audero, Halima Ouadid‐Ahidouch, Julie Schnipper, Luis A. Pardo, Xiaoyi Shi, Frauke Alves, Jakub Mitręga, Anna Trauzold, Sofie E. Hagelund, György Panyi, Marco Cozzolino, Clemens M. W. G. Löwik, Laura Mezzanotte, Roisin McMorrow, Andreas Pahl, Torsten Hechler, Elena Papacharisi, Alessandra Fiorio Pla, Ildiko Szabo, Verena Hofschröer, Zoltán Pethő   +37 more
wiley   +1 more source

Feminists Resist Unrealistic Beauty Standards but Are Not Invulnerable to Their Negative Consequences

Journal of Applied Social Psychology, Volume 56, Issue 4, Page 295-309, April 2026.
ABSTRACT Unrealistic beauty standards have negative effects on women's well‐being. Feminism can act as a protective barrier against these effects by promoting broader beauty standards and resistance to social/gender norms. However, such work often assumes that all feminists are alike.
Joshua J. Tenn, Małgorzata A. Gocłowska, Melissa J. Atkinson   +2 more
wiley   +1 more source

Molecular detection of albinism gene in Brazilian buffalo herds (Bubalus bubalis)

Pesquisa Veterinária Brasileira
: Albinism is a genetic disease characterized by deficient melanin production making affected animals more susceptible to skin problems, negatively influencing production systems of the same.
Pedro N. Bernardino, Aline F.A. Martins, José D. Barbosa, Ana L. Schild, Maria Cecília F. Damé, Alexandre S. Borges, José P. Oliveira-Filho   +6 more
doaj   +1 more source

TKC‐MC: An Effective Strategy for Generating Heritable Heterozygous Mutations in Essential Genes in Rice

Plant Biotechnology Journal, Volume 24, Issue 4, Page 2092-2104, April 2026.
ABSTRACT The CRISPR/Cas9 gene‐editing technology has been widely used in defining gene functions and crop improvement. However, some genes are essential for plant growth and development. Loss‐of‐function homozygous mutations in essential genes lead to plant death or sterility.
Meilian Xu, Lang Yan, Min Zhu, Zhitian Zhan, Hong Chen, Dantong Wang, Zhenping Zheng, Yujie Zhang, Lizhong Xiong, Yubing He   +9 more
wiley   +1 more source

Out from the Shadows [PDF]

, 2014
In East Africa, people with albinism face a bleak fate.
Dubois \u2789, Doug
core   +1 more source

Albinism [PDF]

, 2020
Mohsin H. Ali, Lejla Vajzovic
  +4 more sources

Psychosocial Experiences and Support Resources of People With Albinism: A Thematic Synthesis [PDF]

Journal of Rehabilitation
Objective Albinism is a genetic disease that causes vision limitations and skin and hair problems as a result of a disorder in melanin conversion. This disease can have wide psychosocial consequences among the sufferers.
Taher Alizadeh, Bahman Bahmani, Mohammadsaeed khanjani, Manouchehr Azkhosh, Shima Shakiba, Mohsen Vahedi   +5 more
doaj