Results 101 to 110 of about 125,121 (369)

Urinary Tubular Injury Biomarkers Are Associated With ESRD and Death in the REGARDS Study. [PDF]

, 2018
IntroductionUrinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary kidney injury molecule-1 (uKIM-1) are established markers of subclinical acute kidney injury.
Bennett, Michael, Cushman, Mary, Dubin, Ruth F, Judd, Suzanne, Parikh, Chirag, Peralta, Carmen A, Powe, Neil, Sarnak, Mark, Scherzer, Rebecca, Shlipak, Michael, Warnock, David G   +10 more
core  

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

American Journal of Kidney Diseases, 2019
RATIONALE & OBJECTIVE Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney.
L. Inker, Morgan E. Grams, A. Levey, J. Coresh, M. Cirillo, J. Collins, R. Gansevoort, O. Gutiérrez, T. Hamano, G. Heine, S. Ishikawa, S. Jee, F. Kronenberg, M. Landray, K. Miura, Girish N. Nadkarni, C. Peralta, D. Rothenbacher, E. Schaeffner, S. Sedaghat, M. Shlipak, Luxia Zhang, A. V. van Zuilen, S. Hallan, C. Kovesdy, M. Woodward, A. Levin   +26 more
semanticscholar   +1 more source

Albuminuria Predicts a Rapid Decline in Kidney Function in 2 International, Longitudinal Cohorts of Adults With Sickle Cell Anemia

American Journal of Hematology, EarlyView.
ABSTRACT Chronic kidney disease (CKD) is common and a major contributor to increased morbidity and early mortality in people with sickle cell anemia (SCA). Urine albumin‐to‐creatinine ratio (uACR) is recommended to identify patients with SCA‐related CKD but its utility in predicting long‐term kidney dysfunction remains unclear in this patient ...
Pablo Bartolucci, Étienne Audureau, Vincent Audard, Frédéric Galactéros, Guillaume Lettre, Charmaine Anthony, Olufolake Egbujo, Jin Han, Maria Armila Ruiz, James P. Lash, Victor R. Gordeuk, Xu Zhang, Santosh L. Saraf   +12 more
wiley   +1 more source

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease

Animal Models and Experimental Medicine, EarlyView.
The current study characterized temporal changes in glomerular gene expression, pathology, and biomarkers in a mouse model of hypertension‐accelerated diabetic kidney disease (DKD). Progressive albuminuria and glomerulosclerosis were paralleled by dynamic transcriptomic changes associated withmetabolic dysfunction, extracellular matrix remodeling, and ...
Adam B. Marstrand‐Jørgensen, Frederikke Emilie Sembach, Maria Ougaard, Ditte Hansen, Mette Viberg Østergaard, Henrik H. Hansen, Louise S. Dalbøge, Ole Jørgen Kaasbøll, Michael Christensen   +8 more
wiley   +1 more source

Albuminuria in patients with chronic obstructive pulmonary disease: a cross-sectional study in an African patient cohort

BMC Pulmonary Medicine, 2018
Background Cardiovascular disease (CVD) is remarkably frequent in patients with chronic obstructive pulmonary disease (COPD). Albuminuria is a marker of vascular endothelial dysfunction and predictor of CVD events.
Festo K. Shayo, Janet Lutale
doaj   +1 more source

A gene variant in CERS2 is associated with rate of increase in albuminuria in patients with diabetes from ONTARGET and TRANSCEND. [PDF]

PLoS ONE, 2014
Although albuminuria and subsequent advanced stage chronic kidney disease are common among patients with diabetes, the rate of increase in albuminuria varies among patients.
Dov Shiffman, Guillaume Pare, Rainer Oberbauer, Judy Z Louie, Charles M Rowland, James J Devlin, Johannes F Mann, Matthew J McQueen   +7 more
doaj   +1 more source

The correlates of urinary albumin to creatinine ratio (ACR) in a high risk Australian Aboriginal community [PDF]

, 2013
Background: Albuminuria marks renal disease and cardiovascular risk. It was estimated to contribute 75% of the risk of all-cause natural death in one Aboriginal group.
A Cass, A Festa, A Jager, A Koroshi, A Paolicchi, AM Hodge, C Meisinger, C Tsioufis, DH Lee, DH Lee, DH Lee, DH Lee, EM Stuveling, FC Goetz, GV Prasad, J Cunningham, J Spencer, JB Whitfield, JB Whitfield, JB Whitfield, JC Konen, JH Warram, JR Greenfield, KG Rowley, KL Chien, KM Conigrave, KM Conlgrave, L Bathum, L Huo, M Nakamura, M Veroni, MA Albert, MS Anvari, N Tangri, O Wirta, P Jousilahti, R Drozdz, RJ Glassock, SH Li, SP McDonald, V Agrawal, W Hoy, WE Hoy, WE Hoy, WE Hoy, WE Hoy, Wendy E Hoy, X Guo, YM Smulders, Z Wang, Z Wang, Z Wang, Zaimin Wang, Zhiqiang Wang   +53 more
core   +2 more sources

Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress

Frontiers in Pharmacology, 2018
Albuminuria is an early marker of renovascular damage associated to an increase in oxidative stress. The Munich Wistar Frömter (MWF) rat is a model of chronic kidney disease (CKD), which exhibits endothelial dysfunction associated to low nitric oxide ...
R. González-Blázquez, B. Somoza, M. Gil-Ortega, M. Martín Ramos, David Ramiro-Cortijo, E. Vega-Martín, A. Schulz, L. Ruilope, P. Kolkhof, R. Kreutz, M. Fernández-Alfonso   +10 more
semanticscholar   +1 more source

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source