Results 21 to 30 of about 120,733 (325)

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

JCI Insight, 2023
The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria.
Michael Crompton, J. Ferguson, R. Ramnath, K. L. Onions, A. S. Ogier, M. Gamez, C. Down, L. Skinner, K. Wong, L. Dixon, J. Sutak, S. Harper, P. Pontrelli, L. Gesualdo, H. Heerspink, R. Toto, G. Welsh, R. Foster, S. Satchell, M. Butler   +19 more
semanticscholar   +1 more source

Prevention of cardiorenal damage: importance of albuminuria.

European Heart Journal, 2022
Chronic kidney disease (CKD) is projected to become a leading global cause of death by 2040, and its early detection is critical for effective and timely management.
L. Ruilope, A. Ortiz, A. Lucía, Blanca Miranda, G. Álvarez-Llamas, M. Barderas, M. Volpe, G. Ruiz‐Hurtado, B. Pitt   +8 more
semanticscholar   +1 more source

Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension

Diabetes Epidemiology and Management, 2023
Background: Studies assessing the concordance of albuminuria and retinal microvascular dysfunction (RMD) in type 2 diabetes (T2D) have yielded inconsistent results. Similar to ethnicity, hypertension may be a potential explanatory variable.
Charles Antwi-Boasiako, Kwaku Amponsah Obeng, Kwesi Nyan Amissah-Arthur, Latif Musah, Benjamin Abaidoo, Henry Wedoi Awuviri, Joseph Agyapong Abbey, Pelagia Awula, Ruth Korkor Tei, Charles Agyemang, Albert.G.B. Amoah, Charles F. Hayfron-Benjamin   +11 more
doaj   +1 more source

Fractional Flow Reserve Derived from Computer Tomography in Asymptomatic Patients with Type 2 Diabetes and Albuminuria without Significant Coronary Artery Stenosis—A Surrogate for Coronary Microvascular Dysfunction?

Hearts, 2021
Background: Type 2 diabetes mellitus (T2D) patients with albuminuria have coronary microvascular dysfunction (CMD). Fractional flow reserve assessed by coronary computed tomography angiography (FFRct) is dependent on the structure and function of the ...
Jess Lambrechtsen, Laurits Juhl Heinsen, Johanna Larsson, Gokulan Pararajasingam, Kenneth Egstrup   +4 more
doaj   +1 more source

High Prevalence and Low Awareness of Albuminuria in the Community Setting in the KDSAP

Kidney International Reports, 2020
Introduction: Albuminuria is a sign of kidney disease and associated with adverse outcomes. However, most individuals with albuminuria are unaware of it.
Min Zhuo, Ming-Yan Jiang, Rui Song, Suraj Sarvode Mothi, Sirine Bellou, Laura C. Polding, Jiahua Li, Andrew Cho, Li-Li Hsiao   +8 more
doaj   +1 more source

Albuminuria as a marker of systemic congestion in patients with heart failure

European Heart Journal, 2022
Aims Albuminuria is common in patients with heart failure and associated with worse outcomes. The underlying pathophysiological mechanism of albuminuria in heart failure is still incompletely understood.
E. M. Boorsma, J. T. ter Maaten, K. Damman, B. V. van Essen, F. Zannad, D. V. van Veldhuisen, N. Samani, K. Dickstein, M. Metra, G. Filippatos, C. Lang, Leong L. Ng, S. Anker, J. Cleland, P. Pellicori, R. Gansevoort, H. Heerspink, A. Voors, J. E. Emmens   +18 more
semanticscholar   +1 more source

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +15 more sources

Making an impact on kidney disease in people with type 2 diabetes: the importance of screening for albuminuria

BMJ Open Diabetes Research & Care, 2022
Albuminuria is useful for early screening and diagnosis of kidney impairment, especially in people with pre-diabetes or type 2 diabetes (T2D), which is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease (ESKD), associated with
J. McGill, H. Haller, P. Roy-Chaudhury, A. Cherrington, T. Wada, C. Wanner, L. Ji, P. Rossing   +7 more
semanticscholar   +1 more source

Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea

Frontiers in Cardiovascular Medicine, 2022
IntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g.
Samel Park, Jiyoung Woo, Subeen Leem, Nam Hun Heo, Nam-Jun Cho, Hyowook Gil, Jae Heon Kim, Eun Young Lee, Eun Young Lee, Eun Young Lee   +9 more
doaj   +1 more source

Central obesity and albuminuria: both cross-sectional and longitudinal studies in Chinese. [PDF]

PLoS ONE, 2012
Albuminuria is recognized as a marker of vascular dysfunction. Central obesity increases the risk of cardiovascular disease. Little is known about the association between albuminuria and central obesity in Chinese.
Wen-Yuan Lin, F Xavier Pi-Sunyer, Chiu-Shong Liu, Chia-Ing Li, Lance E Davidson, Tsai-Chung Li, Cheng-Chieh Lin   +6 more
doaj   +1 more source