Results 21 to 30 of about 121,309 (370)

Fractional Flow Reserve Derived from Computer Tomography in Asymptomatic Patients with Type 2 Diabetes and Albuminuria without Significant Coronary Artery Stenosis—A Surrogate for Coronary Microvascular Dysfunction?

Hearts, 2021
Background: Type 2 diabetes mellitus (T2D) patients with albuminuria have coronary microvascular dysfunction (CMD). Fractional flow reserve assessed by coronary computed tomography angiography (FFRct) is dependent on the structure and function of the ...
Jess Lambrechtsen, Laurits Juhl Heinsen, Johanna Larsson, Gokulan Pararajasingam, Kenneth Egstrup   +4 more
doaj   +1 more source

Activation of Rac-1 and RhoA contributes to podocyte injury in chronic kidney disease [PDF]

, 2013
Rho-family GTPases like RhoA and Rac-1 are potent regulators of cellular signaling that control gene expression, migration and inflammation. Activation of Rho-GTPases has been linked to podocyte dysfunction, a feature of chronic kidney diseases (CKD). We
Amann, Kerstin, Babelova, Andrea, Brandes, Ralf Peter Louis, Daniel, Christoph, Fork, Christian, Jansen, Felix, Jung, Oliver, Löhn, Matthias, Pavenstädt, Hermann, Plettenburg, Oliver, Ruetten, Hartmut, Sander, Kerstin, Schäfer, Liliana, Stark, Holger   +13 more
core   +15 more sources

High Prevalence and Low Awareness of Albuminuria in the Community Setting in the KDSAP

Kidney International Reports, 2020
Introduction: Albuminuria is a sign of kidney disease and associated with adverse outcomes. However, most individuals with albuminuria are unaware of it.
Min Zhuo, Ming-Yan Jiang, Rui Song, Suraj Sarvode Mothi, Sirine Bellou, Laura C. Polding, Jiahua Li, Andrew Cho, Li-Li Hsiao   +8 more
doaj   +1 more source

Association between albuminuria and retinal microvascular dysfunction in type 2 diabetes with and without hypertension

Diabetes Epidemiology and Management, 2023
Background: Studies assessing the concordance of albuminuria and retinal microvascular dysfunction (RMD) in type 2 diabetes (T2D) have yielded inconsistent results. Similar to ethnicity, hypertension may be a potential explanatory variable.
Charles Antwi-Boasiako, Kwaku Amponsah Obeng, Kwesi Nyan Amissah-Arthur, Latif Musah, Benjamin Abaidoo, Henry Wedoi Awuviri, Joseph Agyapong Abbey, Pelagia Awula, Ruth Korkor Tei, Charles Agyemang, Albert.G.B. Amoah, Charles F. Hayfron-Benjamin   +11 more
doaj   +1 more source

The Effect of Dapagliflozin on Albuminuria in DECLARE-TIMI 58

Diabetes Care, 2021
OBJECTIVE Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve albuminuria in patients with high cardiorenal risk. We report albuminuria change in the Dapagliflozin Effect on Cardiovascular Events (DECLARE-TIMI 58) cardiovascular outcome trial ...
Ofri Mosenzon, S. Wiviott, Hiddo J. L. Heerspink, J. Dwyer, A. Cahn, Erica L. Goodrich, Aliza Rozenberg, Meir Schechter, Ilan Yanuv, S. Murphy, Thomas A. Zelniker, I. Gause-Nilsson, A. Langkilde, M. Fredriksson, P. Johansson, Deepak L. Bhatt, Lawrence A Leiter, D. McGuire, John P H Wilding, M. Sabatine, I. Raz   +20 more
semanticscholar   +1 more source

Central obesity and albuminuria: both cross-sectional and longitudinal studies in Chinese. [PDF]

PLoS ONE, 2012
Albuminuria is recognized as a marker of vascular dysfunction. Central obesity increases the risk of cardiovascular disease. Little is known about the association between albuminuria and central obesity in Chinese.
Wen-Yuan Lin, F Xavier Pi-Sunyer, Chiu-Shong Liu, Chia-Ing Li, Lance E Davidson, Tsai-Chung Li, Cheng-Chieh Lin   +6 more
doaj   +1 more source

Transiently Observed Trace Albuminuria on Urine Dipstick Test Is Associated With All-Cause Death, Cardiovascular Death, and Incident Chronic Kidney Disease: A National Health Insurance Service-National Sample Cohort in Korea

Frontiers in Cardiovascular Medicine, 2022
IntroductionAlbuminuria is a well-known risk factor for end-stage kidney disease, all-cause mortality, and cardiovascular mortality, even when the albumin-to-creatinine ratio is <30 mg/g.
Samel Park, Jiyoung Woo, Subeen Leem, Nam Hun Heo, Nam-Jun Cho, Hyowook Gil, Jae Heon Kim, Eun Young Lee, Eun Young Lee, Eun Young Lee   +9 more
doaj   +1 more source

Multiomics signatures of type 1 diabetes with and without albuminuria

Frontiers in Endocrinology, 2022
Aims/hypothesisTo identify novel pathophysiological signatures of longstanding type 1 diabetes (T1D) with and without albuminuria we investigated the gut microbiome and blood metabolome in individuals with T1D and healthy controls (HC).
Marc Clos-Garcia, Marc Clos-Garcia, Tarunveer S. Ahluwalia, Tarunveer S. Ahluwalia, Signe A. Winther, Peter Henriksen, Mina Ali, Yong Fan, Evelina Stankevic, Liwei Lyu, Josef K. Vogt, Josef K. Vogt, Torben Hansen, Cristina Legido-Quigley, Peter Rossing, Peter Rossing, Oluf Pedersen, Oluf Pedersen   +17 more
doaj   +1 more source

Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants [PDF]

, 2005
Background/Aim: Phenotype-driven screening of a great pool of randomly mutant mice and subsequent selection of animals showing symptoms equivalent to human kidney diseases may result in the generation of novel suitable models for the study of the ...
Aigner, B., de Angelis, M. H., Klempt, M., Rathkolb, B., Tran, T. V., Wanke, R., Wolf, E.   +6 more
core   +1 more source

Predictors of progression in albuminuria in the general population: results from the PREVEND cohort. [PDF]

PLoS ONE, 2013
BACKGROUND: Urinary albumin excretion is known to be independently associated with progression of renal and cardiovascular disease. The aim of this study was to identify predictors for progression in albuminuria in the general population.
Lieneke Scheven, Nynke Halbesma, Paul E de Jong, Dick de Zeeuw, Stephan J L Bakker, Ron T Gansevoort   +5 more
doaj   +1 more source