Results 51 to 60 of about 121,309 (370)

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease

Nature Communications, 2019
Diabetic kidney disease is a major cause of renal failure that urgently necessitates a breakthrough in disease management. Here we show using untargeted metabolomics that levels of phenyl sulfate, a gut microbiota-derived metabolite, increase with the ...
Koichi Kikuchi, D. Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Paxton Thanai, N. Suzuki, K. Mise, Hiroaki Yamaguchi, Tomohiro Nakamura, K. Asaji, Chikahisa Mukawa, H. Tsukamoto, Toshihiro Sato, Yoshitsugu Oikawa, T. Iwasaki, Yuji Oe, Tomoya Tsukimi, Noriko N. Fukuda, Hsin-Jung Ho, Fumika Nanto-Hara, Jiro Ogura, Ritsumi Saito, S. Nagao, Yusuke Ohsaki, S. Shimada, Takehiro Suzuki, T. Toyohara, Eikan Mishima, Hisato Shima, Yasutoshi Akiyama, Yukako Akiyama, M. Ichijo, Tetsuro Matsuhashi, Akihiro Matsuo, Yoshiaki Ogata, Ching-Chin Yang, Chitose Suzuki, Matthew C. Breeggemann, J. Heymann, M. Shimizu, S. Ogawa, N. Takahashi, Takashi Suzuki, Y. Owada, S. Kure, N. Mano, T. Soga, T. Wada, J. Kopp, S. Fukuda, A. Hozawa, Masayuki Yamamoto, S. Ito, J. Wada, Y. Tomioka, T. Abe   +55 more
semanticscholar   +1 more source

Urinary proteomics using capillary electrophoresis coupled to mass spectrometry for diagnosis and prognosis in kidney diseases [PDF]

, 2016
Purpose of review: Urine is the most useful of body fluids for biomarker research. Therefore, we have focused on urinary proteomics, using capillary electrophoresis coupled to mass spectrometry, to investigate kidney diseases in recent years.
Magalhães, Pedro, Mischak, Harald, Zürbig, Petra   +2 more
core   +1 more source

Immune system deregulation in hypertensive patients chronically RAS suppressed developing albuminuria

Scientific Reports, 2017
Albuminuria development in hypertensive patients is an indicator of higher cardiovascular (CV) risk and renal damage. Chronic renin-angiotensin system (RAS) suppression facilitates blood pressure control but it does not prevent from albuminuria ...
Marta Martin-Lorenzo, Laura Gonzalez-Calero, Paula J. Martinez, Montserrat Baldan-Martin, Juan Antonio Lopez, Gema Ruiz-Hurtado, Fernando de la Cuesta, Julián Segura, Jesús Vazquez, Fernando Vivanco, Maria G. Barderas, Luis M. Ruilope, Gloria Alvarez-Llamas   +12 more
doaj   +1 more source

Tissue lipidomic profiling supports a mechanistic role of the prostaglandin E2 pathway for albuminuria development in glomerular hyperfiltration

Frontiers in Network Physiology, 2023
Background: Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. The Munich Wistar Frömter (MWF) rat is a non-diabetic model of chronic kidney disease (CKD) with GH due to inherited low nephron ...
Debora Kaiser-Graf, Angela Schulz, Eva Mangelsen, Michael Rothe, Juliane Bolbrinker, Reinhold Kreutz   +5 more
doaj   +1 more source

Differential renal effects of candesartan at high-and ultra-high doses in diabetic mice: potential role of  ACE2/AT2R/Mas [PDF]

, 2016
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type 2 ...
Antunes, Tayze, Briones, Ana M., Burns, Kevin, Callera, Glaucia, Correa, Jose, Gutsol, Alexey, He, Ying, Montezano, Augusto C., Moorman, Danielle, Nguyen Dinh Cat, Aurelie, Touyz, Rhian M.   +10 more
core   +1 more source

Childhood Albuminuria and Chronic Kidney Disease is Associated with Mortality and End-Stage Renal Disease

Pediatrics and Neonatology, 2016
We do not yet fully grasp the significance of childhood albuminuria. Based on mass urinary screening (MUS) using albumin-specific dipsticks in school children, we studied the independent association of estimated glomerular filtration rate (eGFR) and ...
Ching-Yuang Lin, Shiuh-Ming Huang
doaj   +1 more source

"FUNCTIONAL ALBUMINURIA." [PDF]

The Lancet, 1889
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openaire   +1 more source

Effect of Intensive Urate Lowering With Combined Verinurad and Febuxostat on Albuminuria in Patients With Type 2 Diabetes: A Randomized Trial.

American Journal of Kidney Diseases, 2020
RATIONALE & OBJECTIVE Hyperuricemia has been implicated in the development and progression of chronic kidney disease (CKD). Verinurad is a novel, potent, specific urate reabsorption inhibitor.
A. Stack, N. Dronamraju, J. Parkinson, S. Johansson, E. Johnsson, F. Erlandsson, R. Terkeltaub   +6 more
semanticscholar   +1 more source

Thyroid function and thyroid homeostasis parameters are associated with increased urinary albumin excretion in euthyroid individuals over 60 years old from NHANES

Frontiers in Endocrinology
IntroductionThe relationship between thyroid function/homeostasis parameters and renal function has been extensively studied. However, the relationship between thyroid function and thyroid homeostasis parameters with albuminuria among elderly individuals
Xue Liu, Xue Liu, Yuchen Li, Yuchen Li, Yuwei Chai, Yuwei Chai, Yuhao Zhang, Li Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang   +11 more
doaj   +1 more source

Improved Time in Range Over 1 Year Is Associated With Reduced Albuminuria in Individuals With Sensor-Augmented Insulin Pump–Treated Type 1 Diabetes

Diabetes Care, 2020
OBJECTIVE To investigate the association between treatment-induced change in continuous glucose monitoring (CGM) time in range (TIR) and albuminuria in persons with type 1 diabetes (T1D) treated with sensor-augmented insulin pumps (SAP).
A. Ranjan, S. Rosenlund, T. Hansen, P. Rossing, S. Andersen, K. Nørgaard   +5 more
semanticscholar   +1 more source