Results 81 to 90 of about 120,733 (325)

Mettl3‐Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS

Advanced Science, EarlyView.
This study explores the roles of Mettl3‐induced N6‐methyladenosine (m6A) modifications in Focal segmental glomerulosclerosis (FSGS). The findings reveal that inhibition of Mettl3 results in podocyte injury by modulating the TJP1CDC42 pathway. Moreover, Administration of N6‐methyladenosine attenuates the FSGS phenotype in WT mice induced by Adriamycin ...
Fubin Zhu, Hongzhi Li, Xiang Li, Chunxiu Du, Ting Wang, Xuling Zhou, Xiaobei Xie, Yunxia Shao, Yingzhi Huang, Yanling Hu, Xinxin Guo, Bin Zhu, Shanshan Yu, Xiaoyan Zhang, Binghai Zhao   +14 more
wiley   +1 more source

FREQUENCY OF MICROALBUMINURIA IN THE MIDDLE AGE AND OLDER POPULATION OF PESHAWAR CITY

Pakistan Armed Forces Medical Journal, 2018
Objectives: To determine the frequency of micro albuminuria in the middle age and older population of both genders in Peshawar city of Pakistan. Study Design: Random control study. Place and Duration of Study: This study was carried out from Jan
Mohammad Yousaf, Muzammil Arshad, Kehkasha Sabir, Ibrahim ., Razaullah .   +4 more
doaj  

The association between weekend warrior physical activity pattern and albuminuria in hypertensive patients

BMC Public Health
Background Albuminuria, a critical and sensitive indicator of vascular injury, has been linked to early kidney damage in patients with hypertension. High-quality physical activity (PA) may reduce urinary albumin excretion.
Bingquan Xiong, Wenlong Yu, Xinyi Guan, Zhuo Tian, Min Zhu, Huiping Yang, Jiaxin Wang, Yingrui Li, Bin Liu, Yufan Wang, Qiang She   +10 more
doaj   +1 more source

Albuminuria status and patterns of dyslipidemia among type 2 diabetes black patients managed at a tertiary health-care hospital: A Post hoc analysis

Saudi Journal of Kidney Diseases and Transplantation, 2018
Cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) increases with the development of albuminuria and is related in part to dyslipidemia. The present analysis assessed lipid profile and patterns of dyslipidemia in T2DM patients according
Francois M Kajingulu, Francois B Lepira, Fiston I Mbutiwi, Jean-Robert Makulo, Ernest K Sumaili, Justine B Bukabau, Vieux M Mokoli, Augustin L Longo, Nazaire M Nseka   +8 more
doaj   +1 more source

The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan

Scientific Reports, 2021
Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients.
Shih-Chen Chang, Chien-Yi Hsu, Li-Kuo Liu, Ya-Wen Lu, Yi-Lin Tsai, Ruey-Hsing Chou, Po-Hsun Huang, Liang-Kung Chen, Shing-Jong Lin   +8 more
doaj   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

High prevalence of albuminuria among adult males living with HIV in Botswana

Scientific Reports
Chronic HIV disease is associated with a fivefold increase in albuminuria outside of sub-Saharan Africa. However, very little is known about albuminuria risk among people living with HIV (PLWH) in sub-Saharan Africa.
Mosepele Mosepele, Ponego Ponatshego, Kesaobaka Molebatsi, Christopher Williams, Lucky Mokgatlhe, Shahin Lockman, Nabila Youssouf, Robert Gross, Joseph Jarvis, Duolao Wang, Shabbar Jaffar   +10 more
doaj   +1 more source

Avaliação dos níveis de albuminúria em adultos obesos e sua associação com marcadores de risco cardiovascular.

HU Revista, 2019
Introdução: A obesidade é um dos fatores mais importantes para explicar o aumento incidência das Doenças Cardiovasculares (DCV). Dentre os múltiplos fatores de risco para estas doenças, a albuminúria é dos mais importantes.
Danielle Braga, Laura Brandao Lemos, Caio Rivelli Silva, Carlos Eduardo Barquette Andrade, Juliana Teixeira Rodrigues Reis, Laura Leite Oliveira, Rodrigo Oliveira Moreira   +6 more
doaj   +1 more source

Kidney disease progression and all-cause mortality across estimated glomerular filtration rate and albuminuria categories among patients with vs. without type 2 diabetes

BMC Nephrology, 2020
Background Studies of progression of kidney dysfunction typically focus on renal replacement therapy or percentage decline in estimated glomerular filtration rate (eGFR) as outcomes.
G. Nichols, Anouk Déruaz-Luyet, K. Brodovicz, T. Kimes, A. Rosales, Sibylle J. Hauske   +5 more
semanticscholar   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source