Results 101 to 110 of about 432,030 (193)

PNPLA3 in Alcohol‐Related Liver Disease

Liver International
ABSTRACTThe discovery of PNPLA3 as a genetic risk factor for liver disease has transformed our understanding of the pathogenesis of alcohol‐related liver disease (ALD). The recent reclassification of fatty liver disease as steatotic liver disease (SLD), introducing metabolic dysfunction and alcohol‐related liver disease (MetALD), has highlighted how ...
Clélia Galvanin, Stephan Buch, Pierre Nahon, Eric Trépo   +3 more
openaire   +2 more sources

Associations between multiple metabolic biomarkers with steatotic liver disease subcategories: A 5-year Chinese cohort study

Cell Reports Medicine
Summary: The effectiveness of established biomarkers for non-alcoholic fatty liver disease (NAFLD) within the updated framework of steatotic liver disease (SLD) remains uncertain.
Hongli Chen, Siyu Chen, Dan Liu, Yebei Liang, Huating Li, Yuqian Bao, Zhijun Zhu, Keqing Dong, Wen Li, Liang Feng, Di Cheng, Fusong Jiang, Li Wei, Xuhong Hou, Weiping Jia   +14 more
doaj   +1 more source

Impact of steatotic liver disease categories on atrial fibrillation in type 2 diabetes: a nationwide study

Scientific Reports
This study aims to investigate the incidence of new-onset atrial fibrillation (AF) in individuals with type 2 diabetes mellitus (T2DM) across different categories of steatotic liver disease (SLD). Using a health examination database between 2009 and 2012,
So Hyun Cho, Gyuri Kim, Kyu-na Lee, Rosa Oh, Ji Yoon Kim, Myunghwa Jang, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim   +10 more
doaj   +1 more source

Central obesity and advanced liver stiffness in Hepatitis B: Result from golestan hepatitis B cohort study [PDF]

, 2015
Background: Chronic infection with the hepatitis B virus and obesity may both contribute synergistically to liver disease, although relatively few studies have investigated this hypothesis.
Besharat, S., Freedman, N.D., Malekzadeh, R., Merat, S., Mohamadkhani, A., Poustchi, H., Roshandel, G.   +6 more
core  

Expression and function of osteopontin variants in HCV-related liver disease and hepatocellular carcinoma. [PDF]

, 2010
Osteopontin (OPN) is a highly secreted multi-functional sialoprotein that is widely expressed in tissues, blood and urine. It is involved in a number of normal physiological functions, but is also significantly elevated in a number of cancers.
Phillips, Renee Jade
core   +1 more source

A comprehensive review of diagnosis and management of alcohol-associated hepatitis

SAGE Open Medicine
Alcohol-associated hepatitis is an extreme form of alcohol-related liver disease associated with high short-term mortality. Currently, there are no authorized therapies for the treatment of severe alcohol-associated hepatitis.
Cyriac Abby Philips
doaj   +1 more source

Phosphatidylethanol and ethyl glucuronide to categorize alcohol consumption in alcohol-related cirrhosis

JHEP Reports
Background & Aims: Phosphatidylethanol (PEth) is an alcohol-use biomarker that could bridge the detection windows of urinary ethyl glucuronide (uEtG) and scalp hair ethyl glucuronide (hEtG), but has been rarely validated in patients with liver ...
Benedict T.K. Vanlerberghe, Catalina Dumitrascu, Nele Van den Eede, Hugo Neels, Hannah van Malenstein, Tom J.G. Gevers, Matthijs Kramer, Lukas Van Melkebeke, Ad A.M. Masclee, Douwe de Boer, Schalk van der Merwe, Frederik Nevens, Alexander L.N. van Nuijs, Jef Verbeek   +13 more
doaj   +1 more source

Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]

, 2015
The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia, Pandol, Stephen J, Waldron, Richard T   +2 more
core   +1 more source

Cognitive impairment in patients awaiting kidney and liver transplantation—A clinically relevant problem?

Brain and Behavior
Introduction Cognitive impairment (CI) is common in both end‐stage kidney disease (ESKD) and alcohol‐related liver cirrhosis. The aim of this study was to assess the prevalence and patterns of CI in patients awaiting kidney and liver transplantation, and
Aleksandra Golenia, Piotr Olejnik, Magdalena Grusiecka‐Stańczyk, Norbert Żołek, Ewa Wojtaszek, Paweł Żebrowski, Joanna Raszeja‐Wyszomirska, Jolanta Małyszko   +7 more
doaj   +1 more source

The contribution of alcohol-use disorder to decompensated cirrhosis among people with hepatitis C: an international comparison study [PDF]

, 2018
Addolorato, Alavi, Aspinall, Behzad Hajarizadeh, Buykx, Chalmers, Collaborators, David J. Goldberg, Dore, El-Serag, Esther J. Aspinall, Friedmann, Gilmore, Grebely, Gregory J. Dore, Hamish Innes, Heather M. Valerio, Innes, Jacob George, Janaki Amin, Janjua, Jason Grebely, Kim, Lazarus, Maryam Alavi, Matthew G. Law, McDonald, McDonald, McLeod, McMahon, Mei Chong, Mel Krajden, Naveed Z. Janjua, Newson, Peter C. Hayes, Rehm, Samji, Sharon J. Hutchinson, Stockwell, Stockwell, Thein, Thompson, Westbrook, Younossi, Zhao   +44 more
core   +1 more source