Results 181 to 190 of about 459,851 (267)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Alcohol consumption and molecular subtypes of colorectal cancer: pooled observational and Mendelian randomization analyses. [PDF]

Am J Clin Nutr
Chalitsios CV, Chan WC, Markozannes G, Aglago EK, Berndt SI, Buchanan DD, Campbell PT, Cao Y, Dimou N, Drew DA, French AJ, Gallinger S, Georgeson P, Giannakis M, Gruber SB, Gunter MJ, Harrison TA, Brenner H, Hoffmeister M, Urruchúa-Rodríguez MJ, Hsu L, Huang WY, Hullar MA, Huyghe JR, Jenkins MA, Jayasekara H, Moreno V, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pellatt AJ, Peoples A, Qu C, Schmit SL, Steinfelder RS, Sun W, Thomas CE, Toland AE, Trinh QM, Ugai T, Um CY, Van Guelpen B, Zaidi SH, Peters U, Phipps AI, Tsilidis KK.   +46 more
europepmc   +1 more source

Frustrated Lewis Pairs and Metallic Ni Synergistically Enabled Low‐Temperature Hydrogenolysis of Lignin Models

Advanced Science, EarlyView.
Nickel–aluminum composite oxide (NiAlOx‐300) derived from NiAl layered double hydroxide showed high activity for hydrogenolysis of various lignin models. Especially, hydrogenolysis of benzyl phenyl ether could be efficiently proceeded at 20°C and 1 MPa H2.
Jinpeng Liang, Ziyi Ma, Zhaoxi Cai, Kongqian Liang, Chenglei Xiao, Sitong Chen, Na Wang, Zhimin Xue, Chao Xie, Jinliang Song   +9 more
wiley   +1 more source

The effect of voluntary chronic alcohol consumption on Th1/Th2 cytokine signature during adolescence in Sprague-Dawley Rats. [PDF]

SAGE Open Med
Moeketsi K, Nkambule BB, Erlwanger KH, Mabasa XE, Maseko MJ, Nyambuya TM.   +5 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Bi+ Cisgender People's Mental Health, Smoking, and Alcohol Consumption as a Function of Their Relationship Configuration. [PDF]

Arch Sex Behav
Amos N, Anderson J, Grant R, Lim G, Hill AO, McNair R, Lyons A, Carman M, Bourne A.   +8 more
europepmc   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

Individual, interpersonal, organizational, and community contexts: factors associated with alcohol consumption among Brazilian adolescents. [PDF]

BMC Pediatr
Coelho LM, Abreu MNS, Ramirez EGL, Cury LS, da Silva AG.   +4 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Moderate alcohol consumption and clinical outcomes in MASLD: a systematic review and meta-analysis of longitudinal cohorts. [PDF]

BMC Gastroenterol
de Souza NS, Cotrim HP, de Andrade ARCF.
europepmc   +1 more source