Results 201 to 210 of about 906,865 (288)
Latent inhibitors of aldehyde dehydrogenase as alcohol deterrent agents
Journal of Medicinal Chemistry, 1984 AbstractDargestellt und pharmakologisch untersucht werden die Analoga (II) von Pargylin (I).
H. Nagasawa +2 more
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Cyanide is a product of the catalase-mediated oxidation of the alcohol deterrent agent, cyanamide
Toxicology Letters, 1987 Cyanide was detected as a product of cyanamide oxidation by bovine liver catalase in vitro under conditions that also produced an active aldehyde dehydrogenase (AlDH) inhibitor. Cyanide formation was directly related to both cyanamide and catalase concentrations and was also dependent on incubation time. The apparent Km for this reaction was 172 microM.
Frances N. Shirota +2 more
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Biochemical Pharmacology, 1998 Nitroxyl, produced in the bioactivation of the alcohol deterrent agent cyanamide, is a potent inhibitor of aldehyde dehydrogenase (AIDH); however, the mechanism of inhibition of AlDH by nitroxyl has not been described previously. Nitroxyl is also generated from Angeli's salt (Na2N2O3) at physiological pH, and, indeed, Angeli's salt inhibited yeast AlDH
Eugene G. DeMaster +2 more
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Nitrosyl cyanide, a putative metabolic oxidation product of the alcohol-deterrent agent cyanamide
Biochemical Pharmacology, 1996 When incubated with catalase/glucose-glucose oxidase, 13C-labeled cyanamide gave rise not only to 13C-labeled cyanide, but also to 13C-labeled CO2. Moreover, a time-dependent formation of nitrite was observed when cyanamide was oxidized in this system. These results suggested that the initial product of cyanamide oxidation, viz. N-hydroxycyanamide, was
Frances N. Shirota +3 more
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Journal of Medicinal Chemistry, 1990 Utilisation de cyanamide marque au 15 N et au 13 C pour mettre en evidence l'intermediaire N-hydroxycyanamide donnant par decomposition le nitroxyle (HN=0), inhibiteur de l'aldehyde deshydrogenase (ALDH)
H. Nagasawa +4 more
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ChemInform, 1987 AbstractThe acylcyanamides (III) and the peptidylcyanamides (IV) are prepared and studied as aldehyde dehydrogenase inhibitors.
Chul‐Hoon Kwon +3 more
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Modified Parallel Tracking and Mapping for Augmented Reality as an Alcohol Deterrent
, 2019 Drug addiction among the population is a major social menace. This paper proposes an innovative method to offer a promising deterrent against alcohol abuse using Augmented Reality (AR) as a tool. The proposed method aims at traumatizing an alcoholic person by augmenting multiple multimedia objects in the vicinity of a person.
Prabhanshu Purwar +3 more
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Journal of Medicinal Chemistry, 1986 Cyanamide (H2NC identical to N), a potent aldehyde dehydrogenase (AlDH) inhibitor that is used therapeutically as an alcohol deterrent agent, is known to be rapidly metabolized and excreted in the urine as acetylcyanamide (1). On the basis of our observation that 1 is deacetylated to cyanamide in vivo, albeit very slightly, thereby serving as a ...
Chul‐Hoon Kwon +3 more
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Citrated Calcium Carbimide/Alcohol Reaction—its Severity and Effectiveness as a Deterrent
British Journal of Addiction to Alcohol & Other Drugs, 1971 C. S. Mellor, Andrew Sims
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Prodrugs of cyanamide as (long-acting) alcohol deterrent agents
Biochemical Pharmacology, 1986 H. Nagasawa +3 more
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