Results 1 to 10 of about 1,814,267 (387)

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis
Akira, Shizuo, Amin, Najaf, Bakalkin, Georgy, Barbieri, Caterina, Baumeister, Sebastian, Boomsma, Dorret I., Cauchi, Stephane, Chambers, John, Chasman, Daniel I., Clarke, Toni-Kim, Daniela, Toniolo, de Geus, Eco, Deary, Ian, Desrivières, Sylvane, Elliott, Paul, Enroth, Stefan, Eriksson, Johan G., Esko, Tõnu, Eulenburg, Volker, Evangelou, Evangelos, Fischer, Krista, Franco, Oscar H., Froguel, Philippe, Gao, He, Gieger, Christian, Grabe, Hans J., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Sarah E., Harris, Tamara B., Hartikainen, Anna-Liisa, Heath, Andrew C., Hieber, Saskia, Hocking, Lynne, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huth, Cornelia, Hällfors, Jenni, Jarvelin, Marjo-Riitta, Jia, Tianye, Johansson, Åsa, Joshi, Peter K., Jukema, J. Wouter, Kaartinen, Niina, Kaprio, Jaakko, Kliewer, Steven A., Kooner, Jaspal S., Kutalik, Zoltan, Lahti, Jari, Laitinen, Jaana, Langenberg, Claudia, Lehtimäki, Terho, Lemaitre, Rozenn, Levy, Daniel, Liu, Chunyu, Liu, Yongmei, Liu, Yun, Loukola, Anu, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Madden, Pamela A.F., Mangelsdorf, David J., Mangino, Massimo, Manichaikul, Ani, Marques-Vidal, Pedro, Martin, Nicholas, Mbarek, Hamdi, Milaneschi, Yuri, Moayyeri, Alireza, Morrison, Alanna, Mukamal, Kenneth, Müller, Christian P., Nelson, Christopher, Nettleton, Jennifer, O'Reilly, Paul, Partinen, Eemil, Penninx, Brenda, Pirastu, Nicola, Preis, Sarah, Psaty, Bruce, Raitakari, Olli, Rawal, Rajesh, Rice, Kenneth M., Ridker, Paul, Robino, Antonietta, Rose, Lynda, Rose, Richard, Rotter, Jerome I., Ruggeri, Barbara, Sala, Cinzia, Samani, Nilesh J., Satoh, Takashi, Schmidt, Helena, Schmidt, Reinhold, Schraut, Katharina, Schumann, Gunter, Scott, Robert, Segura Lepe, Marcelo, Smith, Albert Vernon, Song, Parkyong, Spector, Tim D., Starr, John M., Stott, David, Strachan, David, Teumer, Alexander, Trompet, Stella, Tzoulaki, Ioanna, Uitterlinden, André G., van der Harst, Pim, van Duijn, Cornelia M., Venturini, Cristina, Vergnaud, Anne-Claire, Verweij, Niek, Vitart, Veronique, Vollenweider, Peter, Vuckovic, Dragana, Wareham, Nicholas J., Wedenoja, Juho, Whitfield, John B., Wilson, James, Wolffenbuttel, Bruce, Xu, Bing, Yengo, Loic, Yu, Bing, Zhang, Weihua, Zhao, Jing Hua   +126 more
core   +7 more sources

Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Nature Communications, 2017
Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice ...
Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edwards, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming-Hu Han   +23 more
doaj   +2 more sources

Nucleus Accumbens Shell and mPFC but not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Frontiers in Neuroscience, 2016
Addiction to alcohol remains a major social and economic problem, in part because of the high motivation for alcohol that humans exhibit and the hazardous binge intake this promotes.
Kelly Lei, Scott Wegner, JiHwan Yu, Arisa Mototake, Bing Hu, Frederic Hopf   +5 more
doaj   +2 more sources

Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice [PDF]

Nature Communications
Ovarian-derived estrogen can signal non-canonically at membrane-associated receptors in the brain to rapidly regulate neuronal function. Early alcohol drinking confers greater risk for alcohol use disorder in women than men, and binge alcohol drinking is
Lia J. Zallar, Jean K. Rivera-Irizarry, Peter U. Hamor, Irena Pigulevskiy, Ana-Sofia Rico Rozo, Hajar Mehanna, Dezhi Liu, Jacqueline P. Welday, Rebecca Bender, Joseph J. Asfouri, Olivia B. Levine, Mary Jane Skelly, Colleen K. Hadley, Kristopher M. Fecteau, Scottie Nelson, John Miller, Pasha Ghazal, Peter Bellotti, Ashna Singh, Lauren V. Hollmer, David W. Erikson, Jacob Geri, Kristen E. Pleil   +22 more
doaj   +2 more sources

Association between alcohol drinking frequency and depression among adults in the United States: a cross-sectional study [PDF]

BMC Psychiatry
Background Depression is a major contributor to the global burden of diseases, and alcohol intake is often considered to be associated with depression. However, the relationship between alcohol drinking frequency and depression remains unclear.
Peng Qi, Mengjie Huang, Haiyan Zhu
doaj   +2 more sources

Gender differences in alcohol drinking among adolescents: a school-based survey in China [PDF]

BMJ Open
Background Alcohol drinking among adolescents is associated with their health development. However, the prevalence of alcohol drinking among adolescents in Southwestern China remains largely unexplored.
Yi Liu, Yanhui Liao, Youguo Tan, Yudiao Liang, Ruini He, Jinsong Tang, Shanshan Chen, Zhangming Chen, Silan Ren, Xu Shao, Xiangjuan Kong, Xiaogang Chen   +11 more
doaj   +2 more sources

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

JCI Insight, 2023
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD).
Vicky Chuong, M. Farokhnia, S. Khom, Claire L. Pince, Sophie K. Elvig, R. Vlkolinský, R. Marchette, G. Koob, M. Roberto, L. Vendruscolo, L. Leggio   +10 more
semanticscholar   +1 more source

Alcohol drinking and influencing factors among high school students in Changning District， Shanghai

Shanghai yufang yixue, 2022
ObjectiveTo investigate the alcohol drinking among high school students， determine the possible influencing factors， and provide scientific evidence for effective control of alcohol drinking among high school students.MethodsThis study adopted stratified
QIAN Lei, TANG Chuanxi, WU Jingui
doaj   +1 more source

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder

JAMA psychiatry, 2022
Key Points Question Does psilocybin-assisted treatment improve drinking outcomes in patients with alcohol use disorder relative to outcomes observed with active placebo medication?
M. Bogenschutz, Stephen Ross, Snehal Bhatt, Tara Baron, Alyssa A. Forcehimes, Eugene Laska, S. Mennenga, Kelley C O'Donnell, Lindsey T. Owens, Samantha K. Podrebarac, J. Rotrosen, J. S. Tonigan, Lindsay M Worth   +12 more
semanticscholar   +1 more source

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

International Journal of Molecular Sciences, 2021
Alcohol use disorder remains a substantial social, health, and economic problem and problem drinking levels in women have been increasing in recent years. Understanding whether and how the underlying mechanisms that drive drinking vary by sex is critical
Anna K. Radke, E. Sneddon, Raizel M Frasier, F. Hopf   +3 more
semanticscholar   +1 more source