Results 151 to 160 of about 1,830,234 (387)

Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer

Advanced Science, EarlyView.
Dysregulated RNA splicing is an underappreciated molecular feature of cancer. By integrating murine and cellular models with patient specimens of lung adenocarcinoma, this study demonstrates that RAC1B, rather than RAC1A isoform, promotes tumorigenesis and presents a potent therapeutic target for lung cancer. Mechanistically, RAC1B preferentially binds
Yueren Yan, Ning Wang, Bowen Xing, Min Yang, Jun Shang, Yufang Bao, Lixing Xiao, Ningxia Zhang, Yunpeng Ren, Chunnan Liu, Yuting Chen, Han Han, Yunjian Pan, Lei Lv, Wei‐Xing Zong, Hongbin Ji, Changyou Zhan, Zefeng Wang, Haiquan Chen, Yongbo Wang   +19 more
wiley   +1 more source

Alcohol attitudes and behaviors among faculty at U.S. schools and colleges of pharmacy

Pharmacy Practice, 2011
Despite attempts to control college-aged drinking, binge and underage drinking continues at colleges and universities. Although often underutilized, faculty have the potential to influence students’ behaviors and attitudes towards drinking.
Schlesselman LS, Nobre C, English CD
doaj  

A novel human laboratory alcohol self-administration paradigm for medication screening: Modeling the ability to resist drinking and heavy drinking

Drug and Alcohol Dependence Reports, 2022
Background: Human laboratory analogues of drinking behavior provide an efficient, cost-effective mechanistic evaluation of a medication signal on drinking.
Sherry A. McKee, Terril L. Verplaetse
doaj  

Nucleus Accumbens Shell Orexin-1 Receptors Are Critical Mediators of Binge Intake in Excessive-Drinking Individuals

Frontiers in Neuroscience, 2019
Excessive, binge alcohol drinking is a potent and pernicious obstacle to treating alcohol use disorder (AUD), and heavy-drinking humans are responsible for much of the substantial costs and harms of AUD. Thus, identifying key mechanisms that drive intake
Kelly Lei, Claudina Kwok, David Darevsky, Scott A. Wegner, JiHwan Yu, Lisa Nakayama, Vincent Pedrozo, Lexy Anderson, Shahbaj Ghotra, Mary Fouad, Frederic W. Hopf   +10 more
doaj   +1 more source

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
ENTPD5‐mediated conversion of extracellular adenosine triphosphate to ADP of hepatocytes is critical for maintaining hepatic glucose/lipid metabolism and promoting brown adipose tissue thermogenesis via the inhibition of adrenomedullin expression and secretion.
Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang   +9 more
wiley   +1 more source

A six year longitudinal study of the occupational consequences of drinking over "safe limits" of alcohol. [PDF]

, 1992
Rachel Jenkins, S. Marie Harvey, Tony Butler, Roger L. Thomas   +3 more
openalex   +1 more source

Do Patients with the Sleep Apnea/Hypopnea Syndrome Drink More Alcohol? [PDF]

, 1992
Ryan J. Jalleh, Michael Fitzpatrick, R Mathur, N J Douglas   +3 more
openalex   +1 more source

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

Predictors of quickly progressing from initiating alcohol use to engaging in binge drinking among adolescents

Addictive Behaviors Reports, 2019
Background: A short delay to first intoxication confers alcohol-related risk, but risk factors for a short delay have yet to be examined. Methods: 230 high school students (55.7% male; age 16.52 [1.19] years; 70.9% White) were surveyed about alcohol use.
Meghan E. Morean, Julia Peterson, Alexa L'Insalata   +2 more
doaj  

Harmful alcohol drinking among HIV-positive people in Nepal: an overlooked threat to anti-retroviral therapy adherence and health-related quality of life

Global Health Action, 2018
Background: People living with Human Immunodeficiency Virus (HIV) often suffer from alcohol-use disorders resulting in their poor health and treatment outcomes.
Khem Narayan Pokhrel, Kalpana Gaulee Pokhrel, Sanjeev Raj Neupane, Vidya Dev Sharma   +3 more
doaj   +1 more source