Results 11 to 20 of about 1,830,234 (387)

Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Nature Communications, 2017
Mice exposed to a two-bottle alcohol choice paradigm can be divided into high and low drinking groups. Here, the authors show that stimulating VTA neurons to induce higher phasic activity patterns that are observed in low alcohol drinking mice ...
Barbara Juarez, Carole Morel, Stacy M. Ku, Yutong Liu, Hongxing Zhang, Sarah Montgomery, Hilledna Gregoire, Efrain Ribeiro, Marshall Crumiller, Ciorana Roman-Ortiz, Jessica J. Walsh, Kelcy Jackson, Denise E. Croote, Yingbo Zhu, Song Zhang, Leandro F. Vendruscolo, Scott Edwards, Amanda Roberts, Georgia E. Hodes, Yongke Lu, Erin S. Calipari, Dipesh Chaudhury, Allyson K. Friedman, Ming-Hu Han   +23 more
doaj   +2 more sources

Nucleus Accumbens Shell and mPFC but not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Frontiers in Neuroscience, 2016
Addiction to alcohol remains a major social and economic problem, in part because of the high motivation for alcohol that humans exhibit and the hazardous binge intake this promotes.
Kelly Lei, Scott Wegner, JiHwan Yu, Arisa Mototake, Bing Hu, Frederic Hopf   +5 more
doaj   +2 more sources

KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2016
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis
Akira, Shizuo, Amin, Najaf, Bakalkin, Georgy, Barbieri, Caterina, Baumeister, Sebastian, Boomsma, Dorret I., Cauchi, Stephane, Chambers, John, Chasman, Daniel I., Clarke, Toni-Kim, Daniela, Toniolo, de Geus, Eco, Deary, Ian, Desrivières, Sylvane, Elliott, Paul, Enroth, Stefan, Eriksson, Johan G., Esko, Tõnu, Eulenburg, Volker, Evangelou, Evangelos, Fischer, Krista, Franco, Oscar H., Froguel, Philippe, Gao, He, Gieger, Christian, Grabe, Hans J., Gudnason, Vilmundur, Gyllensten, Ulf, Harris, Sarah E., Harris, Tamara B., Hartikainen, Anna-Liisa, Heath, Andrew C., Hieber, Saskia, Hocking, Lynne, Hofer, Edith, Hofman, Albert, Hottenga, Jouke-Jan, Huth, Cornelia, Hällfors, Jenni, Jarvelin, Marjo-Riitta, Jia, Tianye, Johansson, Åsa, Joshi, Peter K., Jukema, J. Wouter, Kaartinen, Niina, Kaprio, Jaakko, Kliewer, Steven A., Kooner, Jaspal S., Kutalik, Zoltan, Lahti, Jari, Laitinen, Jaana, Langenberg, Claudia, Lehtimäki, Terho, Lemaitre, Rozenn, Levy, Daniel, Liu, Chunyu, Liu, Yongmei, Liu, Yun, Loukola, Anu, Luan, Jian'an, Lyytikäinen, Leo-Pekka, Madden, Pamela A.F., Mangelsdorf, David J., Mangino, Massimo, Manichaikul, Ani, Marques-Vidal, Pedro, Martin, Nicholas, Mbarek, Hamdi, Milaneschi, Yuri, Moayyeri, Alireza, Morrison, Alanna, Mukamal, Kenneth, Müller, Christian P., Nelson, Christopher, Nettleton, Jennifer, O'Reilly, Paul, Partinen, Eemil, Penninx, Brenda, Pirastu, Nicola, Preis, Sarah, Psaty, Bruce, Raitakari, Olli, Rawal, Rajesh, Rice, Kenneth M., Ridker, Paul, Robino, Antonietta, Rose, Lynda, Rose, Richard, Rotter, Jerome I., Ruggeri, Barbara, Sala, Cinzia, Samani, Nilesh J., Satoh, Takashi, Schmidt, Helena, Schmidt, Reinhold, Schraut, Katharina, Schumann, Gunter, Scott, Robert, Segura Lepe, Marcelo, Smith, Albert Vernon, Song, Parkyong, Spector, Tim D., Starr, John M., Stott, David, Strachan, David, Teumer, Alexander, Trompet, Stella, Tzoulaki, Ioanna, Uitterlinden, André G., van der Harst, Pim, van Duijn, Cornelia M., Venturini, Cristina, Vergnaud, Anne-Claire, Verweij, Niek, Vitart, Veronique, Vollenweider, Peter, Vuckovic, Dragana, Wareham, Nicholas J., Wedenoja, Juho, Whitfield, John B., Wilson, James, Wolffenbuttel, Bruce, Xu, Bing, Yengo, Loic, Yu, Bing, Zhang, Weihua, Zhao, Jing Hua   +126 more
core   +7 more sources

Ibudilast reduces alcohol drinking in multiple animal models of alcohol dependence [PDF]

Addiction Biology, 2015
Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets for alcohol dependence. In this study, we examined the ability of ibudilast, a non-selective phosphodiesterase inhibitor, to ...
Becker, Howard C., Bell, Richard L., Cui, Changhai, Egli, Mark, Franklin, Kelle M., Johnson, Kirk W., Lopez, Marcelo F.   +6 more
core   +2 more sources

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

JCI Insight, 2023
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD).
Vicky Chuong, M. Farokhnia, S. Khom, Claire L. Pince, Sophie K. Elvig, R. Vlkolinský, R. Marchette, G. Koob, M. Roberto, L. Vendruscolo, L. Leggio   +10 more
semanticscholar   +1 more source

Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder

JAMA psychiatry, 2022
Key Points Question Does psilocybin-assisted treatment improve drinking outcomes in patients with alcohol use disorder relative to outcomes observed with active placebo medication?
M. Bogenschutz, Stephen Ross, Snehal Bhatt, Tara Baron, Alyssa A. Forcehimes, Eugene Laska, S. Mennenga, Kelley C O'Donnell, Lindsey T. Owens, Samantha K. Podrebarac, J. Rotrosen, J. S. Tonigan, Lindsay M Worth   +12 more
semanticscholar   +1 more source

Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking

International Journal of Molecular Sciences, 2021
Alcohol use disorder remains a substantial social, health, and economic problem and problem drinking levels in women have been increasing in recent years. Understanding whether and how the underlying mechanisms that drive drinking vary by sex is critical
Anna K. Radke, E. Sneddon, Raizel M Frasier, F. Hopf   +3 more
semanticscholar   +1 more source

Three Weeks of Binge Alcohol Drinking Generates Increased Alcohol Front-loading and Robust Compulsive-Like Alcohol Drinking in Male and Female C57BL/6J Mice.

Alcoholism: Clinical and Experimental Research, 2021
BACKGROUND Current models of compulsive-like quinine-adulterated alcohol (QuA) drinking in mice warrant improvements to be more useful for uncovering neural mechanisms of compulsive-like alcohol drinking.
Meredith R. Bauer, Megan M. McVey, S. Boehm   +2 more
semanticscholar   +1 more source

Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults

JAMA Network Open, 2020
Key Points Question Does an association exist between current low to moderate alcohol drinking and cognitive function trajectories or rates of cognitive decline from middle to older age among US adults?
Ruiyuan Zhang, Luqi Shen, T. Miles, Ye Shen, J. Cordero, Yanling Qi, L. Liang, Changwei Li   +7 more
semanticscholar   +1 more source

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

International Journal of Molecular Sciences, 2020
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), increase as the population ages around the world. Environmental factors also play an important role in most cases.
Bin Peng, Qiang Yang, Rachna B Joshi, Yuancai Liu, Mohammed Akbar, B. Song, Shuanhu Zhou, Xin Wang   +7 more
semanticscholar   +1 more source