Results 221 to 230 of about 205,440 (310)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert   +5 more
wiley   +1 more source

Machine learning based on alcohol drinking-gut microbiota-liver axis in predicting the occurrence of early-stage hepatocellular carcinoma. [PDF]

open access: yesBMC Cancer
Yang Y   +14 more
europepmc   +1 more source

Unlocking the Link of Twin Profiles of Plasma Fatty Acids and Genetic Risk and Their Interactions With Incident Dementia

open access: yesFood Frontiers, EarlyView.
Plasma MUFAs, n‐6 PUFAs (particularly LA), and n‐3 PUFAs (particularly non‐DHA n‐3 PUFAs) were found to be inversely associated with dementia risk. The interactions with APOE genotypes and genetic risk score were also observed, as well as the mediation of serum biomarkers. The study highlights the importance of refining plasma fatty acid profiles based
Hao Ye   +11 more
wiley   +1 more source

Mapping Aroma Distribution of Torreya grandis Tissues: A Multisensory Analytical Approach via GC–E–Nose, HS–SPME–GC–MS, and Olfactometry–MS Techniques

open access: yesFood Frontiers, EarlyView.
ABSTRACT Torreya grandis, an economically important nut tree, exhibits significant tissue‐specific aroma profiles, yet the distribution and sensory contributions of its key aroma‐active components remain unclear. This study employed a multimodal analytical approach to systematically characterize the aromatic profiles of different T. grandis tissues. GC–
Zuying Zhang   +11 more
wiley   +1 more source

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