Results 41 to 50 of about 614,273 (365)

Association between long-term alcohol consumption and insomnia symptoms in civil servants: Aichi Workers’ Cohort Study

Fujita Medical Journal, 2022
Objectives: The influence of habitual alcohol consumption on insomnia symptoms in healthy workers remains unclear. In this study, we evaluated the association between habitual alcohol consumption among civil servants and insomnia symptoms such as ...
Motoi Terabe, Tsuyoshi Kitajima, Atsuhiko Ota, Hiroshi Yatsuya, Nakao Iwata   +4 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Nucleus Accumbens Shell and mPFC but not Insula Orexin-1 Receptors Promote Excessive Alcohol Drinking

Frontiers in Neuroscience, 2016
Addiction to alcohol remains a major social and economic problem, in part because of the high motivation for alcohol that humans exhibit and the hazardous binge intake this promotes.
Kelly Lei, Scott Wegner, JiHwan Yu, Arisa Mototake, Bing Hu, Frederic Hopf   +5 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Effect of State Coalitions to Reduce Underage Drinking: A National Evaluation [PDF]

, 2006
Summarizes an evaluation of how the RWJF-funded Reducing Underage Drinking Through Coalitions Project to reduce youth drinking changed media coverage of alcohol-related issues, state policy, youth drinking behaviors, and alcohol-related driving ...
Alexander Wagenaar, Deanna Lewis
core  

Genome-wide association studies of the self-rating of effects of ethanol (SRE). [PDF]

, 2020
The level of response (LR) to alcohol as measured with the Self-Report of the Effects of Alcohol Retrospective Questionnaire (SRE) evaluates the number of standard drinks usually required for up to four effects. The need for a higher number of drinks for
Agrawal, Arpana, Dick, Danielle, Edenberg, Howard J, Farris, Sean, Foroud, Tatiana, Goate, Alison, Goldman, David, Hesselbrock, Victor, Johnson, Emma C, Joslyn, Geoff, Kapoor, Manav, Kramer, John, Lai, Dongbing, Liu, Yunlong, Mayfield, R Dayne, McCutcheon, Vivia V, Nurnberger, John, Porjesz, Bernice, Ramchandani, Vijay A, Rao, Xi, Schuckit, Marc, Schwandt, Melanie, Tischfield, Jay, Wetherill, Leah   +23 more
core   +2 more sources

#BingeDrinking—Using Social Media to Understand College Binge Drinking: Qualitative Study

JMIR Human Factors, 2022
BackgroundHazardous drinking among college students persists, despite ongoing university alcohol education and alcohol intervention programs.
Madison N Cirillo, Jennifer P Halbert, Jessica Gomez Smith, Nour Sami Alamiri, Karen S Ingersoll   +4 more
doaj   +1 more source

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Alcohol consumption in young adults: the role of multisensory imagery. [PDF]

, 2013
Accepted 19.11.2013Little is known about the subjective experience of alcohol desire and craving in young people. Descriptions of alcohol urges continue to be extensively used in the everyday lexicon of young, non-dependent drinkers. Elaborated Intrusion
Andrade, J, Connor, JP, Drennan, J, Feeney, GFX, Fry, M-L, Gullo, MJ, Kavanagh, DJ, May, J, Previte, J, Tjondronegoro, D, White, AM   +10 more
core   +1 more source

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source