Results 21 to 30 of about 12,067 (234)

3‐[3‐(Phenalkylamino)cyclohexyl]phenols: Synthesis, biological activity, and in silico investigation of a naltrexone‐derived novel class of MOR‐antagonists

open access: yesArchiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Based on a simplified version of the morphinan scaffold, 3‐[3‐(phenalkylamino)cyclohexyl]phenol analogues were designed, synthesized and evaluated for their µ‐opioid receptor (MOR) antagonist activity in vitro and in silico. Docking studies indicate a peculiar combination of C‐1 stereochemistry and N‐substitutions as feasibly essential for MOR‐ligand ...
Graziella Tocco   +8 more
wiley   +1 more source

Selective Interventricular Septal Radiofrequency Ablation in Patients With Hypertrophic Obstructive Cardiomyopathy: Who Can Benefit?

open access: yesFrontiers in Cardiovascular Medicine, 2021
Introduction: Septal mass reduction is beneficial for hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular outflow (LVOT) gradient and symptoms, with surgical myectomy or alcohol septal ablation (ASA) currently recommended
Qiang Liu   +23 more
doaj   +1 more source

Hypertrophic Obstructive Cardiomyopathy: Comparison of Outcomes After Myectomy or Alcohol Ablation

open access: yesFrontiers in Cardiovascular Medicine, 2022
Introduction and ObjectivesThe risk of ventricular arrhythmia and heart failure in patients with hypertrophic obstructive cardiomyopathy (HOCM) is much higher than that in the general population.
Xiangbin Meng   +9 more
doaj   +1 more source

In situ synthesis of polyynes in a polymer matrix by pulsed laser ablation in liquid [PDF]

open access: yesRSC Materials Advances 1, 2729 (2020), 2020
Polyynes are finite chains formed by sp-hybridized carbon atoms with alternating single and triple bonds and displaying intriguing electronic and optical properties. Pulsed laser ablation in liquid (PLAL) is a well assessed technique for the physical synthesis of hydrogen-capped polyynes in solution, however, their limited stability prevents further ...
arxiv   +1 more source

How to Harness Electrochemical Mediators for Photocatalysis – A Systematic Approach Using the Phenanthro[9,10‐d]imidazole Framework as a Test Case

open access: yesChemCatChem, Volume 15, Issue 1, January 9, 2023., 2023
The mediator portfolio of electrosynthesis holds untapped potential for photocatalytic applications. A systematic approach toward harnessing electrochemical mediators for photocatalysis is presented using the phenanthroimidazole framework, a known electrocatalytic system, as a test case.
Patrick Enders   +4 more
wiley   +1 more source

Imaging with Diffractive Axicons Rapidly Milled on Sapphire by Femtosecond Laser Ablation [PDF]

open access: yes, 2021
Fabrication of large area (sub 1 cm cross-section) micro-optical components in a short period of time (approximately 10 min) and with lesser number of processing steps is highly desirable and cost-effective. In the recent years, femtosecond laser fabrication technology has revolutionized the field of manufacturing by offering the above capabilities. In
arxiv   +1 more source

Haemodynamic Interplay Between Concomitant Left Ventricular Outflow Tract Obstruction and Aortic Stenosis

open access: yesInterventional Cardiology: Reviews, Research, Resources, 2021
The authors describe a patient with hypertrophic cardiomyopathy with concomitant left ventricular outflow tract obstruction and aortic stenosis. Detailed haemodynamic assessment of the serial lesions was performed.
Priya Bansal   +6 more
doaj   +1 more source

Prognostic value of global longitudinal strain in hypertrophic cardiomyopathy: A systematic review and meta‐analysis

open access: yesClinical Cardiology, Volume 45, Issue 12, Page 1184-1191, December 2022., 2022
Abstract Background As previously reported, impairment of left ventricular global longitudinal strain (LVGLS) is associated with myocardial fibrosis, arrhythmias, and heart failure in hypertrophic cardiomyopathy (HCM) patients. Hypothesis This study aimed to estimate the association between LVGLS measured by echocardiography and major adverse ...
Ying Yang   +3 more
wiley   +1 more source

Alcohol septal ablation for the treatment of hypertrophic obstructive cardiomyopathy in a patient with prior transcatheter aortic valve replacement

open access: yesCardiology Plus, 2020
A 68-year-old man presented with chest distress recurring for the past 10 years. An echocardiogram demonstrated bicuspid aortic valve malformation with severe aortic stenosis and ventricular septal thickness of 22 mm.
Jian-An Wang   +8 more
doaj   +1 more source

Effects of Structural Variations on Antibacterial Properties for Conjugated Diynes Generated through Glaser Hay Couplings

open access: yesChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
A series of conjugated diynes were prepared via both solution phase and solid‐supported Glaser Hay couplings and screened for selective antibacterial activities. A focused structure–activity relationship screen was performed to identify key components of natural product derivatives that were essential for biological activity.
Emma A. Hale   +9 more
wiley   +1 more source

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