Results 1 to 10 of about 658,178 (349)

Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis

Nature Communications, 2021
Alcoholic hepatitis is characterized by intense liver inflammation driven by excessive cytokines and chemokines production and immune cell infiltration. Here the authors identify a super-enhancer that regulates the expression of multiple CXCL chemokines ...
Mengfei Liu, Sheng Cao, Li He, Jinhang Gao, Juan P. Arab, Huarui Cui, Weixia Xuan, Yandong Gao, Tejasav S. Sehrawat, Feda H. Hamdan, Meritxell Ventura-Cots, Josepmaria Argemi, William C. K. Pomerantz, Steven A. Johnsen, Jeong-Heon Lee, Fei Gao, Tamas Ordog, Philippe Mathurin, Alexander Revzin, Ramon Bataller, Huihuang Yan, Vijay H. Shah   +21 more
doaj   +2 more sources

Update on Alcoholic Hepatitis [PDF]

Biomolecules, 2015
Alcoholic liver disease is one of the most prevalent liver diseases worldwide, and a major cause of morbidity and mortality. Alcoholic hepatitis is a severe form of liver injury in patients with alcohol abuse, can present as an acute on chronic liver ...
Natalie J. Torok
doaj   +3 more sources

Recent advances in alcoholic hepatitis [version 1; peer review: 3 approved]

F1000Research, 2020
Alcoholic hepatitis is the severest clinical presentation of alcoholic liver disease. Lacking an effective pharmacologic treatment, alcoholic hepatitis is associated with a poor prognosis and its recovery relies mostly on abstinence.
Vikrant Rachakonda, Ramon Bataller, Andres Duarte-Rojo   +2 more
doaj   +2 more sources

Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients

Gut Microbes, 2020
Background and Aims Alcoholic hepatitis is the most severe form of alcohol-related liver disease. While the gut microbiome is known to play a role in disease development and progression, less is known about specific compositional changes of the gut ...
Sonja Lang, Bradley Fairfied, Bei Gao, Yi Duan, Xinlian Zhang, Derrick E. Fouts, Bernd Schnabl   +6 more
doaj   +2 more sources

Functional Microbiomics Reveals Alterations of the Gut Microbiome and Host Co‐Metabolism in Patients With Alcoholic Hepatitis

Hepatology Communications, 2020
Alcohol‐related liver disease is a major public health burden, and the gut microbiota is an important contributor to disease pathogenesis. The aim of the present study is to characterize functional alterations of the gut microbiota and test their ...
Bei Gao, Yi Duan, Sonja Lang, Dinesh Barupal, Tsung‐Chin Wu, Luis Valdiviez, Bryan Roberts, Ying Yng Choy, Tong Shen, Gregory Byram, Ying Zhang, Sili Fan, Benjamin Wancewicz, Yan Shao, Kevin Vervier, Yanhan Wang, Rongrong Zhou, Lu Jiang, Shilpa Nath, Rohit Loomba, Juan G. Abraldes, Ramon Bataller, Xin M. Tu, Peter Stärkel, Trevor D. Lawley, Oliver Fiehn, Bernd Schnabl   +26 more
doaj   +2 more sources

ALCOHOLIC HEPATITIS

Shock, 2004
Alcoholic hepatitis (AH) is a common disease associated with significant morbidity and mortality. Most often the diagnosis is suggested by a history of heavy alcohol excess in a patient with features of hepatic decompensation. In its purest form, AH is a histologic diagnosis of acute hepatic inflammation in response to alcohol. The primary objective of
Herbert Tilg
  +7 more sources

Infections in Alcoholic Hepatitis. [PDF]

J Clin Transl Hepatol, 2022
Severe alcoholic hepatitis (sAH) is defined by a modified discriminant function ≥32 or model for end-stage liver disease (MELD) >20. Patients with sAH are in an immunocompromised state attributed to cirrhosis-related immunoparesis and corticosteroid use.
Kaur B, Rosenblatt R, Sundaram V.
europepmc   +3 more sources

Alcoholic Hepatitis: A Review [PDF]

Alcohol and Alcoholism, 2019
AbstractAlcoholic liver disease (ALD) represents a spectrum of injury, ranging from simple steatosis to alcoholic hepatitis to cirrhosis. Regular alcohol use results in fatty changes in the liver which can develop into inflammation, fibrosis and ultimately cirrhosis with continued, excessive drinking.
Nooshin Hosseini, Gyongyi Szabo, Julia Shor   +2 more
openaire   +4 more sources

Diagnostic performance of procalcitonin for bacterial infection in severe alcoholic hepatitis compared with C-reactive protein [PDF]

BMC Gastroenterology
Background Severe alcoholic hepatitis is a catastrophic disease with a mortality rate of up to 35–50% at 30 days. Bacterial infection is an important prognostic factor in patients with severe alcoholic hepatitis, but it is difficult to detect the ...
Min Kyu Kang, Yu Rim Lee, Soo Young Park, Kwang Il Seo, Sang Soo Lee, Byung Seok Kim, Jeong Eun Song, Jun Sik Yoon, Young Mi Hong, Ki Tae Yoon, Woo Jin Chung, Seung Ha Park, Eunju Kim, Kyung Ran Jun, Jung Gil Park, Yang-Hyun Baek, Nae-Yun Heo   +16 more
doaj   +2 more sources

Veillonella Bacteremia in Alcoholic Hepatitis [PDF]

Case Reports in Hepatology, 2021
Veillonella species are commensal bacteria of the human oral, gut, and vaginal microbiota that are rarely identified as clinically relevant pathogens.
Patrick Lee, Brandon K. K. Fields, Tom Liang, Michael P. Dubé, Seth Politano   +4 more
doaj   +2 more sources