Results 21 to 30 of about 658,178 (349)

Alcoholic Hepatitis Markedly Decreases the Capacity for Urea Synthesis. [PDF]

PLoS ONE, 2016
Data on quantitative metabolic liver functions in the life-threatening disease alcoholic hepatitis are scarce. Urea synthesis is an essential metabolic liver function that plays a key regulatory role in nitrogen homeostasis.
Emilie Glavind, Niels Kristian Aagaard, Henning Grønbæk, Holger Jon Møller, Nikolaj Worm Orntoft, Hendrik Vilstrup, Karen Louise Thomsen   +6 more
doaj   +1 more source

Pathophysiological Prerequisites and Therapeutic Potential of Fecal Microbiota Transplantation in Severe Alcoholic Hepatitis

Архивъ внутренней медицины, 2022
Due to the high morbidity and mortality, the problem of severe alcoholic hepatitis has not lost its relevance to date. In the absence of specific therapy, the associated to him one-month survival rate is low, and mortality rates reach 30-50 %.
D. V. Garbuzenko
doaj   +1 more source

Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis

Hepatology, 2020
Chronic alcohol consumption causes increased intestinal permeability and changes in the intestinal microbiota composition, which contribute to the development and progression of alcohol‐related liver disease.
S. Lang, Yi Duan, Jinyuan Liu, M. Torralba, Claire Kuelbs, M. Ventura-Cots, J. Abraldes, F. Bosques-Padilla, E. Verna, Robert S. Brown, V. Vargas, J. Altamirano, J. Caballería, D. Shawcross, M. Lucey, A. Louvet, P. Mathurin, G. Garcia‐Tsao, S. Ho, Xin M. Tu, R. Bataller, P. Stärkel, D. Fouts, B. Schnabl   +23 more
semanticscholar   +1 more source

Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis

Biomolecules, 2021
Alcohol-related liver disease is one of the most prevalent liver diseases in the United States. Early stages of alcohol-related liver disease are characterized by accumulation of triglycerides in hepatocytes.
Bei Gao, Josepmaria Argemi, Ramon Bataller, Bernd Schnabl   +3 more
doaj   +1 more source

Fecal Microbiome Distinguishes Alcohol Consumption From Alcoholic Hepatitis But Does Not Discriminate Disease Severity

Hepatology, 2020
The role of the intestinal microbiome in alcoholic hepatitis is not established. The aims of this study were to (1) characterize the fecal microbial ecology associated with alcoholic hepatitis, (2) relate microbiome changes to disease severity, and (3 ...
Ekaterina Smirnova, P. Puri, M. Muthiah, Kalyani Daitya, Robert S. Brown, N. Chalasani, S. Liangpunsakul, V. Shah, Kayla Gelow, M. Siddiqui, Sherry L Boyett, F. Mirshahi, M. Sikaroodi, P. Gillevet, A. Sanyal   +14 more
semanticscholar   +1 more source

Intestinal Virome in Patients With Alcoholic Hepatitis

Hepatology, 2020
Alcoholic hepatitis (AH) is a severe manifestation of alcohol‐associated liver disease (ALD) with high mortality. Although gut bacteria and fungi modulate disease severity, little is known about the effects of the viral microbiome (virome) in patients ...
Lu Jiang, S. Lang, Yi Duan, Xinlian Zhang, Bei Gao, J. Chopyk, Leila K. Schwanemann, M. Ventura-Cots, R. Bataller, F. Bosques-Padilla, E. Verna, J. Abraldes, Robert S. Brown, V. Vargas, J. Altamirano, J. Caballería, D. Shawcross, S. Ho, A. Louvet, M. Lucey, P. Mathurin, G. Garcia‐Tsao, T. Kisseleva, D. Brenner, Xin M. Tu, P. Stärkel, D. Pride, D. Fouts, B. Schnabl   +28 more
semanticscholar   +1 more source

Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis

Hepatology, 2020
Alcoholic hepatitis (AH) is diagnosed by clinical criteria, although several objective scores facilitate risk stratification. Extracellular vesicles (EVs) have emerged as biomarkers for many diseases and are also implicated in the pathogenesis of AH ...
Tejasav S. Sehrawat, J. Arab, Mengfei Liu, P. Amrollahi, Meihua Wan, Jia Fan, Yasuhiko Nakao, E. Pose, Amaia Navarro-Corcuera, Debanjali Dasgupta, Chieh-Yu Liao, Li He, Amy Mauer, E. Avitabile, M. Ventura-Cots, R. Bataller, A. Sanyal, N. Chalasani, J. Heimbach, K. Watt, G. Gores, P. Ginés, P. Kamath, Douglas A. Simonetto, Tony Y. Hu, V. Shah, H. Malhi   +26 more
semanticscholar   +1 more source

In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers.

American Journal of Gastroenterology, 2020
INTRODUCTION Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential.
S. Atkinson, J. Grove, S. Liebig, S. Astbury, N. Vergis, R. Goldin, A. Quaglia, H. Bantel, I. Guha, M. Thursz, P. Newcombe, P. Strnad, G. Aithal   +12 more
semanticscholar   +1 more source

Pentoxifylline in the Treatment of Acute Alcoholic Hepatitis [PDF]

National Journal of Laboratory Medicine, 2014
Background/Aim: It has recently been reported that treatment with pentoxifylline, an inhibitor of tumour necrosis factor, improves survival in severe alcoholic hepatitis.
Arun S, Anjith Vupputur, M Venkatraya Prabhu, Mahesha P , Suresh Shenoy , Pavan M R   +5 more
doaj   +1 more source

Fungi–Bacteria Correlation in Alcoholic Hepatitis Patients

Toxins, 2021
Alcohol-related liver disease is one of the most prevalent types of chronic liver diseases globally. Alcohol-related liver disease begins with fatty liver, which further develops into hepatic inflammation, hepatocyte injury, and progresses to fibrosis ...
Bei Gao, Xinlian Zhang, Bernd Schnabl
doaj   +1 more source