Results 331 to 340 of about 703,542 (394)

Orthotopic liver transplantation [PDF]

, 1995
Gordon, RD, Starzl, TE, Van Thiel, DH
core  

Should We Use Behavioural Predictions in Organ Allocation?

Bioethics, EarlyView.
ABSTRACT Medical predictions, for example, concerning a patient's likelihood of survival, can be used to efficiently allocate scarce resources. Predictions of patient behaviour can also be used—for example, patients on the liver transplant waiting list could receive lower priority based on a high likelihood of non‐adherence to their immunosuppressant ...
Max Drezga‐Kleiminger, Dominic Wilkinson, Thomas Douglas, Joanna Demaree‐Cotton, Julian Koplin, Julian Savulescu   +5 more
wiley   +1 more source

Serum bile acids profiles are altered without change of the gut microbiota composition following a seven-day prednisolone therapy in severe alcoholic hepatitis. [PDF]

Gut Microbes
Esparteiro D, Fouquet G, Courtois A, Jedraszak G, Marticho L, Gourdel M, Billon-Crossouard S, Croyal M, Naassila M, Nguyen-Khac E, Marcq I.   +10 more
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Deacetylation of BAP31 by sirtuin 2 attenuates apoptosis of hepatocytes induced by endoplasmic reticulum stress, in chronic alcoholic liver injury

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Endoplasmic reticulum (ER) stress is a crucial pathogenic mechanism in alcoholic liver disease (ALD). B‐cell receptor‐associated protein 31 (BAP31) can regulate ER homeostasis and anti‐apoptosis, but the function and regulation of BAP31 in ALD are unclear.
Sai Wang, Yufeng Wang, Wen Shan, Guoyang Li, Ran Yan, Zhecheng Wang, Yan Zhao, Jihong Yao, Ning Zhang   +8 more
wiley   +1 more source

Intestinal permeability and immune‐inflammatory markers in patients with idiosyncratic drug‐induced liver injury, drug‐induced steatosis and metabolic dysfunction–associated steatotic liver disease (MASLD)

British Journal of Pharmacology, EarlyView.
Background and Purpose Adverse immuno‐inflammatory responses possibly influenced by bacterial compounds reaching the liver as a consequence of altered intestinal permeability appear to be crucial in the pathogenesis of drug‐induced liver injury and steatotic liver diseases.
Daniel E. Di Zeo‐Sánchez, Irene Díaz‐Alberola, José María Pinazo‐Bandera, Miren García‐Cortés, Judith Sanabria‐Cabrera, Mercedes Robles‐Díaz, Ismael Álvarez‐Álvarez, M. Isabel Lucena, Raúl J. Andrade, Marina Villanueva‐Paz, Camilla Stephens   +10 more
wiley   +1 more source

A Novel Method for Prognostic Risk Classification After Carbon‐Ion Radiotherapy for Hepatocellular Carcinoma Using Data‐Mining Methods

Cancer Science, EarlyView.
First study to use decision tree analysis for predicting cancer‐specific survival after carbon‐ion radiotherapy for hepatocellular carcinoma. Decision tree model offers clear, patient‐friendly prognosis visualization. ABSTRACT No classification methods to predict prognosis after carbon‐ion radiotherapy for hepatocellular carcinoma have yet been ...
Kazuhiko Hayashi, Osamu Suzuki, Koji Ichise, Hirofumi Uchida, Makoto Anzai, Azusa Hasegawa, Shinichi Shimizu, Teruki Teshima, Jiro Fujimoto, Kazuhiko Ogawa   +9 more
wiley   +1 more source

Clonal Hematopoiesis and Solid Cancers

Cancer Science, EarlyView.
This review explores the relationship between clonal hematopoiesis and solid cancers. Clonal hematopoiesis mutations influence the tumor microenvironment by altering immune regulation, inflammation, and angiogenesis. Understanding these mutations has important clinical implications, including their role in prognosis, treatment response, and potential ...
Yen T. M. Nguyen, Manabu Fujisawa, Shumpei Ishikawa, Mamiko Sakata‐Yanagimoto   +3 more
wiley   +1 more source

Atypical Presentation of Homozygous UROD Mutation: Porphyria Cutanea Tarda or Mild Hepatoerythropoietic Porphyria?

Clinical Genetics, EarlyView.
We report a patient homozygous for the UROD c.185C>T (p.P62L) variant who presents with clinical features resembling familial porphyria cutanea tarda (PCT). This case highlights the limitations of rigid UROD‐related porphyria classifications and supports the existence of a phenotypic continuum modulated by genetic, epigenetic, and environmental factors.
Pedro Gabriel Dotto, Mônica Ribeiro de Azevedo Vasconccellos, José Francisco da Silva Franco, Caio Perez Gomes, João Bosco Pesquero   +4 more
wiley   +1 more source