Results 191 to 200 of about 172,158 (311)

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Molecular Characterization of Patatin-Like Phospholipase Domain-Containing 3 (PNPLA3) Gene in Alcoholic Liver Disease. [PDF]

Cureus
N S, Biradar S, Kadakol GS, Kadagud A, Utnal AH, Chandraiah R.   +5 more
europepmc   +1 more source

Diagnostic Accuracy of Serological Markers in Viral Hepatitis and Non Alcoholic Fatty Liver Disease. A Comparative Study in Tertiary Care Hospital of Western Nepal

, 1970
Ankush Mittal, Brijesh Sathian, N Chandrasekharan, Akshay Lekhi, Shamim Mohammad Farooqui, Naresh Pandey   +5 more
openalex   +2 more sources

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Discovery of an AKT1-targeting compound from a traditional herbal formula for alcoholic liver disease via integrative computational and experimental approaches. [PDF]

Chin Med
Yang S, Zou C, Li D, Lin J, Chen Q, Chen M, Wu C, Hung A, Liu Y, Sun X, Li H, Wang Q, Zhao X.   +12 more
europepmc   +1 more source

[P1–428]: NON‐ALCOHOLIC FATTY LIVER DISEASE AND CEREBRAL SMALL‐VESSEL DISEASE IN COGNITIVELY NORMAL INDIVIDUALS [PDF]

, 2017
Hyemin Jang, Danbee Kang, Yeshin Kim, Ko Woon Kim, Jin San Lee, Young Kyoung Jang, Duk L. Na, Hee Young Shin, Mira Kang, Eliseo Güallar, Juhee Cho, Sang Won Seo   +11 more
openalex   +1 more source

USP9X as a Candidate Mediator of Prenatal Aspirin‐Induced Ovarian Reserve Reduction in Offspring Mice

Advanced Science, EarlyView.
This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li, Caiyun Ge, Wai Yen Yim, Hui Feng, Tiancheng Wu, Lu Chen, Qiaohua Xiong, Shumin Pan, Mei Wang, Huijun Chen, Yuanzhen Zhang, Hui Wang   +11 more
wiley   +1 more source

Intervention Potential of a Recombinant Tarim Red Deer HGF Protein in a Mouse Model of Alcoholic Liver Disease. [PDF]

Biology (Basel)
Chen H, Lin C, Xiang X, Yang C, Han C, Gao Q.   +5 more
europepmc   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

The Beneficial Effects of Ethanol Extract of the Microalga <i>Phaeodactylum tricornutum</i> in Alcoholic Liver Disease. [PDF]

Int J Mol Sci
Kim DY, Shin SC, Kim GJ, Eom JI, Han CH, Pan CH, Lee JK.   +6 more
europepmc   +1 more source