TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Honey Lemon Alleviates Alcoholic Liver Disease via Multi-Target Synergistic Mechanisms: An Integrated Study of Network Pharmacology, Molecular Docking, and Animal Experiments. [PDF]
Zhou Y +8 more
europepmc +1 more source
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou +8 more
wiley +1 more source
A Prospective Observational Study of AUDIT-based Risk Stratification and Drinking Guidance Provided by Hepatologists in Patients with Alcoholic Liver Disease. [PDF]
Nomura N +10 more
europepmc +1 more source
Effect of <i>Porphyromonas gingivalis</i> lipopolysaccharide administration on non-alcoholic liver disease in Medaka fish. [PDF]
Ueki A +5 more
europepmc +1 more source
Lactobacillus reuteri targets farnesoid X receptor-dependent bile acid homeostasis to ameliorate alcoholic liver disease. [PDF]
Yuan S +11 more
europepmc +1 more source
[Burden and epidemiological trends of alcohol use disorder and alcoholic liver disease in the Asia-Pacific region]. [PDF]
Zhuang QC, Yang CQ.
europepmc +1 more source
A rare case report on diabetes insipidus following living donor liver transplantation in patient with alcoholic liver disease. [PDF]
Shanmugam V, Shankar BA.
europepmc +1 more source
Alcoholic Liver Disease and Systemic Inflammatory Response Syndrome: Mortality Prediction Using Biomarkers and Clinical Scores. [PDF]
Glisic T +9 more
europepmc +1 more source

