Results 191 to 200 of about 938,793 (293)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh   +19 more
wiley   +1 more source

NAADF: Globally Illuminated Voxel Worlds Accelerated with Nested Axis‐Aligned Distance Fields

open access: yesComputer Graphics Forum, EarlyView.
Abstract Achieving realistic rendering of 3D scenes in real time using path tracing is challenging due to the high sample count required, with ray tracing as the bottleneck. Focusing on voxels as a geometry representation offers significant opportunities for optimizations, especially for tracing the rays, but also for computing the samples.
A. Ulschmid   +4 more
wiley   +1 more source

Spiders in the mosaic: How habitat heterogeneity and structure drive local spider diversity in a Mediterranean forest

open access: yesEcological Entomology, EarlyView.
We assessed alpha‐ and beta‐diversity patterns of spiders across different forests and across vegetation layers (ground, shrub, low canopy) at local spatial scales across various Mediterranean forest types. Across forests, alpha‐diversity increased with habitat heterogeneity, which also drove beta‐diversity patterns across plots .
Manuel Marquerie‐Córdoba   +8 more
wiley   +1 more source

Emerging Techniques in Minimally Invasive Surgery in Hematologic Malignancies

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Hematologic malignancies represent the most common cancers in children. While the mainstays of treatment are chemotherapy and potentially hematopoietic stem cell transplant, minimally invasive surgery (MIS) has a role in the diagnosis and management of complications related both to disease and therapy as well as common pediatric surgical ...
Alejandro Chara   +3 more
wiley   +1 more source

Abnormal cleavage patterns in equine in vitro‐produced embryos lead to higher early pregnancy loss

open access: yesEquine Veterinary Journal, EarlyView.
Summary Background Despite significant advances, in vitro production (IVP) of equine embryos continues to lack standardised embryo classification criteria and is associated with increased rates of early pregnancy loss compared with in vivo‐derived blastocysts.
Soledad Martin‐Pelaez   +6 more
wiley   +1 more source

Home - About - Disclaimer - Privacy