Results 51 to 60 of about 3,638,759 (260)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

H.A.R. Gibb ve Onun Arap Dili ve Kur’an Bağlamında İslâm Algısı

İslami İlimler Dergisi, 2018
ÖzBu çalışma, çağdaş İngiliz oryantalistlerden Arap dilinde ve İslâm konusundakapsamlı araştırmaları ile tanınan Sir Hamilton Alexander RoskeenGibb’in kısaca hayatı ve eserlerini, Arap dili ve Kur’ân hakkındaki yaklaşımlarınıesas alarak onun İslâm ...
Yusuf Seller
doaj  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Apocalyptic reflections in the studies of the Russian orthodox priest Alexander Men

Cхід, 2019
The relevance of the article is due to the increased interest in the cultural heritage of the last century. The creative achievements and worldviews of priest Alexander Men, which are a significant component of the spiritual Russian culture, have been ...
Maria Bardyn
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

A Teoria das Cooperativas Camponesas de Alexander Chayanov

Estudos Sociedade e Agricultura, 2018
Resenha do livro Teoria das Cooperativas Camponesas de Alexander Chayanov. Palavras-chave: Alexander Chayanov; cooperativas camponesas. CHAYANOV, Alexander. A Teoria das Cooperativas Camponesas de Alexander Chayanov.
Zenicleia Angelita Deggerone
doaj   +2 more sources

The Gate of Alexander in Hebrew Alexander Romances

Classica Cracoviensia, 2016
The Gate of Alexander in Hebrew Alexander Romances However surprising it may seem, the story of the gate of Alexander in the Hebrew versions of the Romance is associated rather with certain geographical and historical facts than with the ...
Aleksandra Klęczar
doaj   +1 more source

Twisted Alexander polynomials on curves in character varieties of knot groups [PDF]

, 2013
For a fibered knot in the 3-sphere the twisted Alexander polynomial associated to an SL(2,C)-character is known to be monic. It is conjectured that for a nonfibered knot there is a curve component of the SL(2,C)-character variety containing only finitely
Kim, Taehee, Kitayama, Takahiro, Morifuji, Takayuki   +2 more
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source