Results 61 to 70 of about 3,638,759 (260)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
She Ji: The Journal of Design, Economics and Innovation, 2020 This is a commentary on Per Galle’s review of the work of Christopher Alexander. Galle covers the classic book A Pattern Language and the later four-volume The Nature of Order. Alexander spent many decades deriving a geometrical basis for beauty.
Nikos A. Salingaros
doaj +1 more source
, 2022 Peter Alexander (eigentl. Peter Alexander Neumayer, 1926–2011), österr. Sänger, Schauspieler und Entertainer (s. Eintrag »Peter, oder Alexander«)
Straub, Wolfgang +2 more
openaire +2 more sources
Alexander Bird: _Thomas Kuhn_ [PDF]
, 2002 This is a review of Alexander Bird's book on Thomas ...
Sankey, Howard
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
To Sogdiana and back: Demodamas, the Branchidae, and Apollo Didymeus [PDF]
Studia HercyniaThe massacre of the Branchidae in Sogdiana still stands as one of the most controversial milestones of Alexander’s career. Modern assessments of this event have been highly polarized, but how was it perceived both by contemporary writers and the citizens
Marc Mendoza
doaj
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Plutarch's Alexander the Great as Focus for Greek Identity
Classica Cracoviensia, 2014 Plutarch's Alexander the Great as Focus for Greek Identity. The Case of Alexander's Childhood and Youth in Vira Alexandri The present paper concentrates on the character of Plutarch’s Alexander and his idealized Greek traits as visible in one ...
Aleksandra Klęczar
doaj +1 more source
Twisted Alexander Polynomials of $(-2,3,2n+1)$-Pretzel Knots [PDF]
, 2018 We calculate the twisted Alexander polynomials of $(-2,3,2n+1)$-pretzel knots associated to their holonomy representations. As a corollary, we obtain new supporting evidences of Dunfield, Friedl and Jackson's conjecture, that is, the twisted Alexander ...
Aso, Airi +2 more
core +2 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source