Biotechnology and Bioengineering, EarlyView.ABSTRACT Adeno‐associated viral (AAV) vectors for gene therapy are becoming integral to modern medicine, providing therapeutic options for diseases once deemed incurable. Currently, viral vector purification is a critical bottleneck in the gene therapy industry, impacting product efficacy and safety as well as accessibility and cost to patients ...
Kelvin P. Idanwekhai +9 more
wiley +1 more source
Transfer Learning Approaches in Bioprocess Engineering: Opportunities and Challenges
Biotechnology and Bioengineering, EarlyView.ABSTRACT Transfer learning (TL) has recently emerged as a promising approach to overcoming one of the key limitations of bioprocess engineering: data scarcity. By leveraging knowledge from one bioprocess to another, TL allows existing models and data sets to be reused efficiently, accelerating process development, improving prediction accuracy, and ...
Daniel Barón Díaz +3 more
wiley +1 more source
Glial fibrillary acidic protein is pathologically modified in Alexander disease. [PDF]
J Biol ChemLin NH, Jian WS, Snider N, Perng MD.
europepmc +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Leukodystrophy with Macrocephaly, Refractory Epilepsy, and Severe Hyponatremia-The Neonatal Type of Alexander Disease. [PDF]
Genes (Basel)Paprocka J +4 more
europepmc +1 more source
How wildlife respond to tropical cyclones: short‐term tactics and long‐term impacts
Biological Reviews, EarlyView.ABSTRACT From butterflies to lizards and from sharks to seabirds, wildlife exhibit tactics to survive the impacts of tropical cyclones, also known as hurricanes, cyclones, or typhoons depending on where they occur. Some species seek refuge during the storm by moving, some remain in place and ride it out, and others move longer distances, avoiding the ...
Erin L. Koen +15 more
wiley +1 more source
Validation of a molecular diagnostic algorithm for leishmania detection in a non-endemic setting
International Journal of Infectious Diseases, 2014 R. Lau +4 more
doaj +1 more source
Adult-Onset Alexander Disease With Late-Presenting Vestibulopathy: A Case Report. [PDF]
J Mov DisordChang HJ, Jeong SH, Oh E.
europepmc +1 more source
Genres and their implications: Meddlesomeness in on curiosity versus the lives [PDF]
, 2008 Van Hoof, Lieve
core +1 more source
Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife
Biological Reviews, EarlyView.ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief +4 more
wiley +1 more source