Results 61 to 70 of about 22,922,487 (300)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The Cathedral of St Alexander Nevski in Sofia. [PDF]
, 2008 Previously in the University eprints HAIRST pilot service at http://eprints.st-andrews.ac.uk/archive/00000393/Article 4 of 6 in an issue devoted to the visual culture of South Eastern EuropeBuilt to celebrate the liberation of Bulgaria from centuries of ...
Leandro, Gloria.
core +2 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Construyendo Ciudadanía # 114 – SINEP Alexander Largacha
, 2022 En este episodio se aborda el Sistema de Información de la Educación del Sector Público (SINEP), destacando su importancia en la gestión y organización de la información institucional.
Hernández Hurtado, Juan
core
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Efficiency of Using Tuned Mass Damper to Reduce Damage after Strong Earthquakes
MATEC Web of Conferences, 2018 The efficiency of applying tuned mass damper is substantiated for reducing the damageability of structures under strong earthquakes. Two models of structure damage accumulation are considered.
Benin Andrei +2 more
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Steeplechase photograph from the Alexander G. Olsen Papers
, 1920 Black-and-white photograph of horses and riders during steeplechase, from the Alexander G. Olsen Papers, date and location unknown.Alexander G. Olsen graduated from Norwich University with a degree in civil engineering in 1920.
Olsen, Alexander G., born 1894;
core +2 more sources
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source