Results 31 to 40 of about 93,773 (261)

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Nursing fate : configurations of childhood in the Libro de Alexandre

Estudios de Historia de España, 2017
The present work deals with the double challenge of considering childhood as a concept when apprehending it from a theoretical point of view and with its own historicity as a starting point, that is, taking into account a particular space and period of ...
Jezabel Koch
doaj  

D’Orient en Orients: à l’est de Rome, du nouveau

Cuadernos de Historia Moderna, 2023
Le 16e siècle romain correspond au déploiement au long cours de sa connaissance et redéfinition de l’Orient, à la croisée de multiples savoirs et pratiques, savantes ou ordinaires, qui redessinent les liens entre Antiquité et monde contemporain.
Antonella Romano
doaj   +1 more source

MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Mapping the role of industry 4.0 technologies in green supply chain management: a bibliometric and structured text analysis

Discover Sustainability
The Fourth Industrial Revolution, or Industry 4.0 (I4.0), is transforming industrial passages globally through the leverage of digital technologies, such as artificial intelligence (AI), machine learning (ML), big data analytics (BDA), blockchain, and ...
Khouloud Challouf, Abdelkarim Alhloul, Nikoletta Nemeth   +2 more
doaj   +1 more source

Agenesis of the right lung in an adult woman: A case report

Clinical Case Reports, 2023
Key Clinical Message Pulmonary agenesis is a rare congenital abnormality. Patients with hemithorax white‐out on x‐rays should be treated with caution, especially in resource‐limited countries where chest CT and bronchofibroscopy are not available to ...
Elias Gonçalves, Ofélia Sachicola, Bartolomeu Estanislau, Francisca Quifica, Humberto Morais, Margarete Arrais   +5 more
doaj   +1 more source

Revealing the Nanoscale Morphology Changes of Polymer Electrolyte Membrane Fuel Cell Catalyst Layers due to Conditioning

Advanced Science, EarlyView.
We apply ex situ and in situ scanning transmission X‐ray microscopy to reveal the structural degradation of polymer electrolyte membrane fuel cell catalyst layers due to conditioning and thermal heating of the catalyst coated membrane. We observe a redistribution of the ionomer and carbon‐black in the catalyst layer, as well as nanoscale membrane ...
Spencer Lytle, Harsharaj B. Parmar, Jian Wang, Shohei Yamashita, Aimy Bazylak   +4 more
wiley   +1 more source

Analog Weight Update Rule in Ferroelectric Hafnia, Using picoJoule Programming Pulses

Advanced Electronic Materials, EarlyView.
Resistive, ferroelectric synaptic weights based on BEOL‐compatible hafnia/zirconia nanolaminates are fabricated. Lateral downscaling the devices below 10 µm2 enables 20 ns programming with electrical pulses, dissipating ≤ 3 pJ. Experimental results show that final conductance state is set by pulse amplitude, and is largely independent of the initial ...
Alexandre Baigol, Nikhil Garg, Matteo Mazza, Yanming Zhang, Elisa Zaccaria, Wooseok Choi, Bert Jan Offrein, Laura Bégon‐Lours   +7 more
wiley   +1 more source

Geographical approach of Industry 4.0 based on information and communication technologies at Hungarian enterprises in connection with industrial space

Hungarian Geographical Bulletin, 2020
In the short history of Hungarian industry there were relevant changes several times, which had a great impact not only on industrial production and employment, but also on the spatial pattern of industry.
Éva Kiss, Erzsébet Nedelka
doaj   +1 more source