Results 11 to 20 of about 302,669 (151)

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology [PDF]

open access: yesMovement Disorders, Volume 41, Issue 5, Page 1128-1140, May 2026.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +2 more sources

A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity [PDF]

open access: yesBMC Medicine
Background The Omicron lineage of SARS-CoV-2 showed a remarkable ability to escape vaccine-induced immunity. In a Phase 2 clinical trial, we investigated whether a third booster/fifth dose of one of three inactivated SARS-CoV-2 vaccine candidates, based ...
Constanza Méndez   +39 more
doaj   +2 more sources

The XBB.1.5 mRNA booster vaccine does not significantly increase the percentage of XBB.1.5 mono-reactive T cells [PDF]

open access: yesFrontiers in Immunology
Recent efforts in vaccine development have targeted spike proteins from evolving SARS-CoV-2 variants. In this study, we analyzed T cell responses to the XBB.1.5 and BA.2.86 subvariants in individuals who previously received bivalent vaccines containing ...
Joel Sop   +9 more
doaj   +2 more sources

Influenza vaccines promote humoral and cellular immune responses: a randomized, double-blind, phase 3 trial [PDF]

open access: yesNature Communications
Annual vaccination is an effective strategy for preventing severe disease caused by seasonal influenza. Quadrivalent influenza vaccines (QIVs) protect against two strains of influenza A and two strains of influenza B, thereby enhancing the host antiviral
Linmar Rodríguez-Guilarte   +38 more
doaj   +2 more sources

Allelic variation of Avr genes in highly virulent strains explains severe wheat stem rust epidemics [PDF]

open access: yesNature Communications
Wheat stem rust is a disease of global importance caused by the fungal pathogen Puccinia graminis f. sp. tritici (Pgt). Here we generate chromosome-level, nuclear-phased genome references for Pgt isolates ETH2013-1 and ITA2018-1, representing races TKTTF
Rebecca E. Spanner   +23 more
doaj   +2 more sources

Age and primary vaccination schedule impact humoral and cellular immunity with an inactivated SARS-CoV-2 vaccine [PDF]

open access: yesiScience
Summary: Despite widespread COVID-19 vaccination, questions remain about vaccine safety and immunogenicity in vulnerable populations, such as older adults. We evaluated the safety and immunogenicity of four doses of CoronaVac in adults above and below 60
Yohana Martínez-Balboa   +35 more
doaj   +2 more sources

Removal of Azo Dyes from Water Using Natural Luffa cylindrica as a Non-Conventional Adsorbent [PDF]

open access: yesMolecules
Reducing high concentrations of pollutants such as heavy metals, pesticides, drugs, and dyes from water is an emerging necessity. We evaluated the use of Luffa cylindrica (Lc) as a natural non-conventional adsorbent to remove azo dye mixture (ADM) from ...
Ma. Guadalupe Aranda-Figueroa   +7 more
doaj   +2 more sources

Maternal experience of intimate partner violence, maternal depression, and parental stress are not associated with child telomere length in Bangladesh [PDF]

open access: yesScientific Reports
Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of telomere shortening is accelerated in response to stress and is well characterized in adult populations from high ...
Diego Figueroa   +31 more
doaj   +2 more sources

Combinatorial Synthesis of Protein–Polymer Conjugates by Postpolymerization Modification of Poly(pentafluorophenyl acrylate)s [PDF]

open access: yesACS Omega
Emily W. Kish   +8 more
doaj   +2 more sources

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