Results 231 to 240 of about 838,557 (301)

More Than a Question of Correlation: Characterization of the Evidentiary Basis for Biomarker Surrogates Used in European Marketing Authorizations

Clinical Pharmacology &Therapeutics, EarlyView.
Traditionally, clinical outcomes measuring how a patient feels, functions, or survives are preferred endpoints in clinical trials; however, some may take a long time to manifest in slowly developing diseases. Biomarkers, if properly validated, can serve as surrogate endpoints, acting as substitutes for clinical outcomes.
Renske Johanna Grupstra, Viktoriia Starokozhko, Elisabeth Bakker, Anna Maria Gerdina Pasmooij, Peter Gerardus Maria Mol   +4 more
wiley   +1 more source

Rapid Symptomatic Improvement and Long-Term Minimal Symptom Expression in a Myasthenia Gravis Patient Treated With Zilucoplan Without Maintenance Cholinesterase Inhibitors, Corticosteroids, or Immunosuppressants: A Case Report. [PDF]

Cureus
Amano R.
europepmc   +1 more source

Efficacy and safety of ropeginterferon alfa-2b in the treatment of polycythemia vera: a systematic review with single arm meta-analysis. [PDF]

Ann Hematol
Nada EA, Elfagieh MA, Abdelsalam F, Elrashedy AA, Idres FA, Shata A, Othman AM, Hamoud HMM, Awadalla RM, Qutob IA, Hamed BM.   +10 more
europepmc   +1 more source

Phenotype and genotype of hypophosphatasia cases in Saudi Arabia: multi-center case cohort. [PDF]

Front Genet
Alsagheir A, Mcrabi A, Alquayt M, Alhuthil R, Alawi A, Faqeih E, Alabdullatif AT, Homyani DA, AlJohany A, AlOtaibi M, Rabea M, AlSayed H, Al-Hamed MH.   +12 more
europepmc   +1 more source

Rarely listed essential medicines in 158 national lists. [PDF]

J Pharm Policy Pract
Ul Haq MZ, Heredia C, Rizvi A, Workentin A, Persaud N.   +4 more
europepmc   +1 more source

The quadruple immunotherapy for colorectal cancer (QuICC) trial for mismatch repair-proficient metastatic colorectal cancer. [PDF]

Oncologist
Bracken-Clarke D, Pastor DM, Marté JL, Donahue RN, Hodge JW, Cordes L, Floudas CS, Tschernia NP, Karzai F, Brownell I, Turkbey EB, Soon-Shiong P, Schlom J, Gulley JL, Maeng HM, Strauss J, Redman JM.   +16 more
europepmc   +1 more source