Results 51 to 60 of about 7,508 (277)
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source
Applying model-driven paradigm: CALIPSOneo experience [PDF]
, 2013 Model-Driven Engineering paradigm is being used by the research community in the last years, obtaining suitable results. However, there are few practical experiences in the enterprise field. This paper presents the use of this paradigm in an aeronautical
Escalona Cuaresma, María José +4 more
core
Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1
FEBS Letters, EarlyView.Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji +5 more
wiley +1 more source
Dokumenttien hallintajärjestelmän valinta Ovako Bar Oy Ab:lle [PDF]
, 2010 Opinnäytetyön tarkoituksena oli sopivan dokumenttien hallintajärjestelmän etsiminen Ovako Bar Oy Ab:n teknisen kunnossapidon tarpeisiin. Aineisto kerättiin haastattelujen, tuote-esittelyjen ja kyselyjen avulla. Sopivia järjestelmiä etsittiin tutustumalla
Anttonen, Heidi, Naukkarinen, Riikka
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Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Projeto Action for Age 2: o processo do Design no design de serviços [PDF]
, 2012 This paper aims to show the design process of a project developed by the Design students of the Universidade de Aveiro. The project is part of a wide challenge launched to all Portuguese Design Universities called “Action for Age”.
Costa, Rui Carlos +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Types and degrees of interpretive resemblance in translation [PDF]
, 2001 This articles explores one of the types of interpretive resemblance found in translation, namely, resemblance between concepts. These are cases where the concept encoded involves a resemblance relation between its literal import and the meaning it ...
О.П. Космач +1 more
core +3 more sources
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source