Results 41 to 50 of about 7,147,076 (289)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A Knowledge Representation and Reasoning System for Multimodal Neuroimaging Studies

Inteligencia Artificial, 2017
Multimodal neuroimaging analyses are of major interest for both research and clinical practice, enabling the combined evaluation of the structure and function of the human brain. These analyses generate large volumes of data and consequently increase the
Ana Coelho, Paulo Marques, Ricardo Magalhães, Nuno Sousa, José Neves, Victor Alves   +5 more
doaj   +1 more source

Cylindrical Algebraic Decomposition Using Local Projections

, 2014
We present an algorithm which computes a cylindrical algebraic decomposition of a semialgebraic set using projection sets computed for each cell separately.
Strzebonski, Adam
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Bounds on Herman's algorithm

, 2014
Herman's self-stabilisation algorithm allows a ring of $N$ processors having any odd number of tokens to reach a stable state where exactly one token remains.
Haslegrave, John
core   +1 more source

Patient privacy in smart cities by blockchain technology and feature selection with Harris Hawks Optimization (HHO) algorithm and machine learning [PDF]

, 2022
Haedar Emad Sharef Alsafi, Jorge Munilla, Javad Rahebi   +2 more
openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Dense symmetric temporal alignment learning for human pose estimation [PDF]

PeerJ Computer Science
Human pose estimation aims to locate the human joint positions from images or videos. This problem has drawn increasing attention and wide applications in autonomous driving, motion analysis, and intelligence robotics.
Guang Xv, Xingchen Wu
doaj   +2 more sources

State Transition Algorithm

, 2012
In terms of the concepts of state and state transition, a new heuristic random search algorithm named state transition algorithm is proposed. For continuous function optimization problems, four special transformation operators called rotation ...
A. H. Wright, A. K. Qin, C. Hamzacebi, C. Hamzacebi, D. D. Burgess, D. E. Goldberg, D. H. Wolpert, D. W. Stroock, F. J. Solis, F. V. Berth, G. Albeanu, G. Rudolph, H. A. Abbass, J. A. Nelder, J. C. Lagarias, J. J. Liang, J. Kennedy, J. Matyas, J. Y. Li, K. Deb, K. F. C. Yiu, P. Collet, R. C. Eberhart, R. Hooke, R. Storn, T. D. Tran, T. W. Leung, T. Zhang, X. J. Zhou, X. J. Zhou, X. S. Yang, Y. H. Shi, Y. X. Yuan, Z. Michalewicz   +33 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source