Advanced Science, EarlyView.Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy +4 more
wiley +1 more source
Advanced Science, EarlyView.Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang +3 more
wiley +1 more source
Quality and reliability of osteoarthritis-related health information on short video platforms: a cross-sectional comparative study of TikTok and Bilibili. [PDF]
Front Digit HealthZuo QH +8 more
europepmc +1 more source
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Enhancing media literacy to combat information fragmentation in digital short video platforms: a cross-sectional study. [PDF]
Sci RepYu T, Wei C, Na M, Alam SS.
europepmc +1 more source
MELEGROS: Monolithic Elephant‐Inspired Gripper with Optical Sensors
Advanced Science, EarlyView.MELEGROS is a monolithic, elephant‐inspired soft gripper integrating 3D‐printed optical sensors within a pneumatically actuated lattice. Simulation‐guided design decouples tactile and proprioceptive sensing. Characterized through grasping tests, MELEGROS can reach, scoop, and grasp, showcasing a paradigm where fully embedded sensing and continuous ...
Petr Trunin +4 more
wiley +1 more source
Because You Watched: How Do Streaming Services' Recommender Systems Influence Aesthetic Choice? [PDF]
Behav Sci (Basel)Chapman HE, Abraham A.
europepmc +1 more source
Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells
Advanced Science, EarlyView.This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh +11 more
wiley +1 more source
Using Large Language Models for In Silico Development and Simulation of a Patient-Reported Outcome Questionnaire for Cataract Surgery with Various Intraocular Lenses: A Pre-Validation Study. [PDF]
J Clin MedTrojacka E +6 more
europepmc +1 more source