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Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

open access: yesAdvanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji   +10 more
wiley   +1 more source

Identifying, Measuring and Contesting Algorithmically Curated Misinformation

Companion Publication of the 2021 Conference on Computer Supported Cooperative Work and Social Computing, 2021
This research examines the role of algorithms driving the online platforms in surfacing misinformation. Specifically, my dissertation work explores how can we ethically develop scalable audit pipelines to identify, measure and contest algorithmically curated misinformation.
openaire   +1 more source

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