Results 41 to 50 of about 35,088 (292)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Gendered Digital Harms and Youth Ideological Trajectories: Socioconomic Challenges of Digital Platforms [PDF]
SocioEconomic ChallengesThe exponential expansion of algorithmic systems has intensified digital harms, particularly in the Global South. This paper investigates the embedded role of AI-driven digital platforms in producing gendered digital harms and shaping youth ideological ...
Patrick Agyare
doaj +1 more source
Platforms, the First Amendment and Online Speech: Regulating the Filters [PDF]
, 2019 In recent years, online platforms have given rise to multiple discussions about what their role is, what their role should be, and whether they should be regulated. The complex nature of these private entities makes it very challenging to place them in a
Grafanaki, Sofia
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Meaning in the Algorithmic Museum: Towards a Dialectical Modelling Nexus of Virtual Curation
HeritageThe rise of algorithm-driven virtual museums presents a philosophical challenge for how cultural meaning is constructed and critiqued in digital curation. Prevailing approaches highlight important but partial aspects: the loss of aura and authenticity in
Huining Guan, Pengbo Chen
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
From static to dynamic evaluation: The potentials and challenges of dashboards to account for NRSs
Big Data & SocietyRecommender systems are dynamic systems used across digital platforms that personalize curation based on the individuals’ history of interactions. News recommender systems (NRSs) can enhance personal relevance and loyalty while reducing the power laws of
Árni Már Einarsson, Jacob Ørmen
doaj +1 more source
Social Media + Society, 2019 This article investigates the logics that underpin music curation, and particularly the work of music curators, working at digital music streaming platforms.
Tiziano Bonini, Alessandro Gandini
doaj +1 more source
Catching the flu: Syndromic surveillance, algorithmic governmentality and global health security [PDF]
, 2016 How do algorithms shape the imaginary and practice of security? Does their proliferation point to a shift in the political rationality of security? If so, what is the nature and extent of that shift?
Dutt A +8 more
core +4 more sources